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一种新发现的水疱性口炎病毒——卡尔查基病毒,以及来自阿根廷的梅劳病毒和马瓜里病毒的亚型,有人类和马匹感染的血清学证据。

A newly recognized vesiculovirus, Calchaqui virus, and subtypes of Melao and Maguari viruses from Argentina, with serologic evidence for infections of humans and horses.

作者信息

Calisher C H, Monath T P, Sabattini M S, Mitchell C J, Lazuick J S, Tesh R B, Cropp C B

出版信息

Am J Trop Med Hyg. 1987 Jan;36(1):114-9. doi: 10.4269/ajtmh.1987.36.114.

DOI:10.4269/ajtmh.1987.36.114
PMID:2880522
Abstract

In 1983, 17 virus strains were isolated from mosquitoes collected during an outbreak of western equine encephalitis in Santa Fe Province, Argentina. Strains of western equine encephalitis, Venezuelan equine encephalitis, St. Louis encephalitis, and Antequera viruses were isolated, as were several bunyaviruses of the California and Bunyamwera serogroups and a new vesiculovirus. Complement fixation and neutralization tests were used to identify the California serogroup virus as a subtype of Melao virus, the Bunyamwera serogroup virus as a subtype of both Maguari and Playas viruses, and the vesiculovirus as a newly recognized agent for which the name Calchaqui virus is proposed. A limited serosurvey of horses and humans in Santa Fe Province and horses from the adjacent Santiago del Estero Province was performed to determine the prevalence of neutralizing antibody to the subtypes of Melao and Maguari viruses and to Calchaqui virus. The high prevalence of antibodies to these three agents indicates the need for further studies of their disease potential in horses, because they are closely related to several other viruses that are known equine pathogens.

摘要

1983年,从阿根廷圣菲省西部马脑炎疫情期间采集的蚊子中分离出17种病毒株。分离出了西部马脑炎病毒株、委内瑞拉马脑炎病毒株、圣路易斯脑炎病毒株和安特克拉病毒株,以及加利福尼亚血清群和布尼亚姆韦拉血清群的几种布尼亚病毒和一种新的水疱性病毒。采用补体结合试验和中和试验,将加利福尼亚血清群病毒鉴定为梅劳病毒的一个亚型,将布尼亚姆韦拉血清群病毒鉴定为马瓜里病毒和普拉亚斯病毒的一个亚型,将水疱性病毒鉴定为一种新发现的病原体,并提议将其命名为卡尔查基病毒。对圣菲省的马匹和人类以及相邻的圣地亚哥-德尔埃斯特罗省马匹进行了有限的血清学调查,以确定针对梅劳病毒和马瓜里病毒亚型以及卡尔查基病毒的中和抗体的流行情况。针对这三种病原体的抗体高流行率表明,有必要进一步研究它们在马匹中的致病潜力,因为它们与其他几种已知的马病原体密切相关。

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