Abul-Haija Yousef M, Scott Gary G, Sahoo Jugal Kishore, Tuttle Tell, Ulijn Rein V
WestCHEM/Department of Pure and Applied Chemistry, University of Strathclyde, 295 Cathedral Street, Glasgow G1 1XL, UK.
Chem Commun (Camb). 2017 Aug 24;53(69):9562-9565. doi: 10.1039/c7cc04796g.
Peptide co-assembly is of interest for the development of functional supramolecular biomaterials. Herein, computational simulations were combined with experimental validation to aid the design and understanding of cooperative co-assembly of a structure-forming tripeptide (FFD) and a functional copper-binding tripeptide (GHK) leading to hydrogel formation in response to complexation with copper ions.
肽的共组装对于功能性超分子生物材料的开发具有重要意义。在此，通过计算模拟与实验验证相结合的方式，辅助设计并理解一种结构形成三肽（FFD）和一种功能性铜结合三肽（GHK）的协同共组装过程，该过程在与铜离子络合时会形成水凝胶。
