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Multiple myeloma with extramedullary disease: impact of autologous stem cell transplantation on outcome.

作者信息

Kumar L, Gogi R, Patel A K, Mookerjee A, Sahoo R K, Malik P S, Sharma A, Thulkar S, Kumar R, Biswas A, Sharma O D, Gupta R

机构信息

Department of Medical Oncology, Institute Rotary Cancer Hospital, All India Institute of Medical Sciences, New Delhi, India.

Department of Radio-diagnosis, Institute Rotary Cancer Hospital, All India Institute of Medical Sciences, New Delhi, India.

出版信息

Bone Marrow Transplant. 2017 Oct;52(10):1473-1475. doi: 10.1038/bmt.2017.165. Epub 2017 Aug 14.

DOI:10.1038/bmt.2017.165
PMID:28805789
Abstract
摘要

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Reduced relapse rate in upfront tandem autologous/reduced-intensity allogeneic transplantation in multiple myeloma only results in borderline non-significant prolongation of progression-free but not overall survival.多发性骨髓瘤患者接受前期串联自体/减低强度异基因移植后复发率降低，仅使无进展生存期得到临界性的非显著性延长，而总生存期未延长。
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Am J Hematol. 2017 Oct;92(10):E611-E614. doi: 10.1002/ajh.24857. Epub 2017 Aug 17.
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Using depth of response to stratify patients to front line Autologous Stem Cell Transplant: results of the phase II PADIMAC Myeloma Trial.利用缓解深度对患者进行一线自体干细胞移植分层：II期PADIMAC骨髓瘤试验结果
Br J Haematol. 2021 May;193(3):e19-e22. doi: 10.1111/bjh.17391. Epub 2021 Mar 14.
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本文引用的文献

1
Autologous stem cell transplantation for multiple myeloma: Long-term results.多发性骨髓瘤的自体干细胞移植：长期结果
Natl Med J India. 2016 Jul-Aug;29(4):192-199.
2
Revised International Staging System for Multiple Myeloma: A Report From International Myeloma Working Group.多发性骨髓瘤修订国际分期系统：国际骨髓瘤工作组报告
J Clin Oncol. 2015 Sep 10;33(26):2863-9. doi: 10.1200/JCO.2015.61.2267. Epub 2015 Aug 3.
3
Incidence and clinical features of extramedullary multiple myeloma in patients who underwent stem cell transplantation.
髓外多发性骨髓瘤：挑战与机遇
Curr Oncol. 2025 Mar 20;32(3):182. doi: 10.3390/curroncol32030182.
4
VRd vs. VPd as induction therapy in high risk newly diagnosed multiple myeloma.VRd与VPd作为新诊断高危多发性骨髓瘤诱导治疗的比较
Sci Rep. 2025 Mar 22;15(1):9946. doi: 10.1038/s41598-025-85398-0.
5
The impact of high-risk cytogenetic abnormalities in extramedullary multiple myeloma in the era of novel agents: insights from a multicenter study.新型药物时代高危细胞遗传学异常对髓外多发性骨髓瘤的影响：一项多中心研究的见解
BMC Cancer. 2024 Dec 18;24(1):1551. doi: 10.1186/s12885-024-13309-z.
6
Risk factors of early disease progression and decreased survival for multiple myeloma patients after upfront autologous stem cell transplantation.初诊自体干细胞移植后多发性骨髓瘤患者早期疾病进展和生存降低的风险因素。
Ann Hematol. 2024 Aug;103(8):2893-2904. doi: 10.1007/s00277-024-05641-y. Epub 2024 Mar 13.
7
Survival trends and prognostic factors of patients with newly diagnosed multiple myeloma accompanied with extramedullary disease.新诊断的伴有髓外疾病的多发性骨髓瘤患者的生存趋势和预后因素。
Ann Med. 2023;55(2):2281657. doi: 10.1080/07853890.2023.2281657. Epub 2023 Dec 12.
8
A prognostic model for patients with primary extramedullary multiple myeloma.原发性髓外多发性骨髓瘤患者的预后模型
Front Cell Dev Biol. 2022 Nov 25;10:1021587. doi: 10.3389/fcell.2022.1021587. eCollection 2022.
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Clin Med Insights Oncol. 2022 Jul 18;16:11795549221109500. doi: 10.1177/11795549221109500. eCollection 2022.
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Front Oncol. 2022 Jul 7;12:934240. doi: 10.3389/fonc.2022.934240. eCollection 2022.
接受干细胞移植患者的髓外多发性骨髓瘤的发病率及临床特征
Br J Haematol. 2015 Jun;169(6):851-8. doi: 10.1111/bjh.13383. Epub 2015 Apr 1.
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The t(11;14)(q13;q32) translocation as a poor prognostic parameter for autologous stem cell transplantation in myeloma patients with extramedullary plasmacytoma.t(11;14)(q13;q32)易位作为髓外浆细胞瘤骨髓瘤患者自体干细胞移植的不良预后参数。
Clin Lymphoma Myeloma Leuk. 2015 Apr;15(4):227-35. doi: 10.1016/j.clml.2014.12.007. Epub 2014 Dec 12.
5
Features of extramedullary disease of multiple myeloma: high frequency of p53 deletion and poor survival: a retrospective single-center study of 834 cases.多发性骨髓瘤髓外疾病的特征：p53缺失频率高及生存率低：一项对834例病例的回顾性单中心研究
Clin Lymphoma Myeloma Leuk. 2015 May;15(5):286-91. doi: 10.1016/j.clml.2014.12.013. Epub 2015 Jan 3.
6
Superiority of bortezomib, thalidomide, and dexamethasone (VTD) as induction pretransplantation therapy in multiple myeloma: a randomized phase 3 PETHEMA/GEM study.硼替佐米、沙利度胺和地塞米松（VTD）作为多发性骨髓瘤移植前诱导治疗的优势：一项随机 3 期 PETHEMA/GEM 研究。
Blood. 2012 Aug 23;120(8):1589-96. doi: 10.1182/blood-2012-02-408922. Epub 2012 Jul 12.
7
Extramedullary disease portends poor prognosis in multiple myeloma and is over-represented in high-risk disease even in the era of novel agents.髓外疾病预示着多发性骨髓瘤的预后不良，即使在新型药物时代，高风险疾病中也存在过度表达。
Haematologica. 2012 Nov;97(11):1761-7. doi: 10.3324/haematol.2012.065698. Epub 2012 Jun 11.
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Soft-tissue plasmacytomas in multiple myeloma: incidence, mechanisms of extramedullary spread, and treatment approach.多发性骨髓瘤中的软组织浆细胞瘤：发生率、髓外扩散的机制和治疗方法。
J Clin Oncol. 2011 Oct 1;29(28):3805-12. doi: 10.1200/JCO.2011.34.9290. Epub 2011 Sep 6.
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Long-term prognostic significance of response in multiple myeloma after stem cell transplantation.干细胞移植后多发性骨髓瘤反应的长期预后意义。
Blood. 2011 Jul 21;118(3):529-34. doi: 10.1182/blood-2011-01-332320. Epub 2011 Apr 11.
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Incidence, presenting features and outcome of extramedullary disease in multiple myeloma: a longitudinal study on 1003 consecutive patients.多发性骨髓瘤髓外疾病的发病情况、表现特征和转归：对 1003 例连续患者的纵向研究。
Ann Oncol. 2010 Feb;21(2):325-330. doi: 10.1093/annonc/mdp329. Epub 2009 Jul 24.