Smith S S, Waterhouse B D, Chapin J K, Woodward D J
Brain Res. 1987 Jan 6;400(2):353-9. doi: 10.1016/0006-8993(87)90634-2.
In this study, the neuromodulatory effects of progesterone were tested in an intact neuronal circuit of a model extrahypothalamic CNS area. Spontaneous discharge and responses of single cerebellar Purkinje neurons to microiontophoretically applied gamma-aminobutyric acid (GABA) and glutamate were monitored before, during and after either systemic injection, at physiologic doses, or local application of the steroid. By both means of administration, progesterone significantly enhanced inhibitory responses of Purkinje cells to GABA and suppressed glutamate excitation within 3-10 min post-steroid. These results are consistent with the anxiolytic actions of the steroid.
在本研究中，我们在一个模型下丘脑外中枢神经系统区域的完整神经回路中测试了孕酮的神经调节作用。在全身注射生理剂量的类固醇或局部应用该类固醇之前、期间和之后，监测单个小脑浦肯野神经元的自发放电以及对微量离子电泳施加的γ-氨基丁酸（GABA）和谷氨酸的反应。通过这两种给药方式，孕酮在类固醇给药后3 - 10分钟内显著增强了浦肯野细胞对GABA的抑制反应，并抑制了谷氨酸兴奋。这些结果与该类固醇的抗焦虑作用一致。
