Friedrich Reinhard E, Luebke Andreas M, Amling Michael, Koehne Till
Professor, Department of Oral and Maxillofacial Surgery, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Head, Department of Orthopedic Pathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
J Oral Maxillofac Surg. 2018 Feb;76(2):336-346. doi: 10.1016/j.joms.2017.07.150. Epub 2017 Jul 20.
Paget disease of bone (PDB) is a chronic progressive bone disorder characterized by localized increased bone turnover and focal areas of woven bone formation. Although skull involvement is common, PDB very rarely affects the mandible. This report describes the clinical and histologic findings in a 75-year-old patient with PDB involving the mandible. Microstructural analyses showed an altered quality of the bone microstructure and calcium depletion of the affected bone. Differential diagnosis of PDB affecting the mandible is discussed.
骨佩吉特病（PDB）是一种慢性进行性骨疾病，其特征为局部骨转换增加和编织骨形成的局灶性区域。虽然颅骨受累很常见，但PDB极少影响下颌骨。本报告描述了一名75岁下颌骨受累的PDB患者的临床和组织学表现。微观结构分析显示骨微观结构质量改变以及受累骨的钙耗竭。文中讨论了影响下颌骨的PDB的鉴别诊断。
