Department of Organic and Polymer Materials Chemistry, Faculty of Engineering, Tokyo University of Agriculture and Technology, Japan.
Department of Organic and Polymer Materials Chemistry, Faculty of Engineering, Tokyo University of Agriculture and Technology, Japan.
Colloids Surf B Biointerfaces. 2017 Nov 1;159:318-326. doi: 10.1016/j.colsurfb.2017.08.004. Epub 2017 Aug 4.
In the present study, by using a newly developed one-step emulsification technique, we tried to prepare porous PLGA particles having a proper diameter and surface morphology in order to achieve both a high efficient delivery of the particles to the lungs and a phagocytosis-avoidance ability. We found that our porous particles have the very low tapped density of 0.04g/cm. Experimental and theoretical studies strongly suggest that the shape factor should not be determined only by the outline of the particles, although previous research assigned a value of 1 to the shape factor for particles regardless of the presence of pores and their distribution. We found the possibility that our porous particles both had specific internal structures induced by spontaneous emulsification and exhibited unusual aerodynamic performance.
在本研究中，我们采用新开发的一步乳化技术，尝试制备具有适当粒径和表面形态的多孔 PLGA 颗粒，以实现颗粒向肺部的高效传递和吞噬避免能力。我们发现我们的多孔颗粒具有非常低的振实密度为 0.04g/cm³。实验和理论研究强烈表明，形状因子不应仅由颗粒的轮廓决定，尽管以前的研究将形状因子的值分配给了无论是否存在孔及其分布的颗粒。我们发现，我们的多孔颗粒可能具有由自发乳化引起的特定内部结构，并表现出异常的空气动力学性能。
