Eskiizmir G, Ozgur E, Karaca G, Temiz P, Yanar N Hacioglu, Ozyurt B Cengiz
Department of Otolaryngology - Head and Neck Surgery,Celal Bayar University,Manisa,Turkey.
Department of Otolaryngology - Head and Neck Surgery Clinic,Bigadic State Hospital,Balikesir,Turkey.
J Laryngol Otol. 2017 Oct;131(10):889-894. doi: 10.1017/S0022215117001669. Epub 2017 Aug 15.
To determine the locoregional control and survival rates (in terms of risk factors) of patients who underwent surgical resection of early-stage lip cancer and for whom a 'wait and see' policy in terms of neck status had been implemented.
The sociodemographic data, tumour stage, tumour characteristics and histopathological features of 41 patients with early-stage lip cancer were evaluated. Factors predictive of survival and locoregional recurrence were analysed. The five-year overall survival and disease-free survival rates were determined, and the prognostic risk factors were compared.
The mean follow-up period was 60.5 months (range, 4-92 months). Age, sex, tumour stage, tumour thickness and volume, and perineural involvement were not predictive of locoregional recurrence or survival. Pathological tumour stage (T1 vs T2) was a prognostic factor for both five-year overall survival (87.3 vs 65.6 per cent, p = 0.042) and disease-free survival (88.6 vs 65.6 per cent, p = 0.037).
Tumour stage was clearly a major factor affecting the prognosis of surgically treated patients with early-stage lip cancer for whom a 'wait and see' policy in terms of neck status had been implemented.
确定接受早期唇癌手术切除且在颈部状况方面实施“观察等待”策略的患者的局部区域控制率和生存率（根据风险因素）。
评估41例早期唇癌患者的社会人口统计学数据、肿瘤分期、肿瘤特征和组织病理学特征。分析生存和局部区域复发的预测因素。确定五年总生存率和无病生存率，并比较预后风险因素。
平均随访期为60.5个月（范围4 - 92个月）。年龄、性别、肿瘤分期、肿瘤厚度和体积以及神经周围侵犯均不能预测局部区域复发或生存。病理肿瘤分期（T1与T2）是五年总生存率（87.3%对65.6%，p = 0.042）和无病生存率（88.6%对65.6%，p = 0.037）的预后因素。
对于接受手术治疗且在颈部状况方面实施“观察等待”策略的早期唇癌患者，肿瘤分期显然是影响其预后的主要因素。
