丙型肝炎病毒与慢性肾脏病的关系：同质性产生异质性。
Association between hepatitis C virus and chronic kidney disease: heterogeneity begets heterogeneity.
机构信息
Department of Medicine, Division of Infectious Diseases, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA.
出版信息
Kidney Int. 2017 Sep;92(3):546-548. doi: 10.1016/j.kint.2017.04.023.
Abstract
Epidemiologic studies examining the association between hepatitis C virus and chronic kidney disease have yielded conflicting findings. Analyzing data from a Taiwanese cohort, Lai and colleagues report a novel finding that the odds of chronic kidney disease were nearly 3-fold higher in hepatitis C virus-infected persons with genotype 2 compared with genotype 1. Hepatitis C virus genotype distributions differ in regions around the world. Can genotypic differences in chronic kidney disease risk explain some of the heterogeneity in prior studies?
摘要
流行病学研究检查丙型肝炎病毒与慢性肾脏病之间的关系，结果并不一致。赖和他的同事们分析了来自台湾队列的数据，报告了一个新发现，与基因型 1 相比，基因型 2 的丙型肝炎病毒感染者发生慢性肾脏病的几率几乎高出 3 倍。世界各地丙型肝炎病毒基因型的分布有所不同。慢性肾脏病风险的基因型差异是否可以解释先前研究中的一些异质性？
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