Mast Isa H, Allard Neeltje A E, Ten Haaf Dominique, Stoffels Anouk A F, Janssen Lando, van Hees Hieronymus W H, Timmers Silvie, Hijmans-Kersten Bregina T P, Hopman Maria T E, Buffart Laurien M
Department of Medical BioSciences, Radboud University Medical Center, Nijmegen, The Netherlands.
FrieslandCampina, Amersfoort, The Netherlands.
Physiol Rep. 2024 Dec;12(23):e70134. doi: 10.14814/phy2.70134.
Knowledge of muscle contractile properties, physical fitness, and their associations with perceived fatigue may provide insights into mechanisms inducing fatigue and treatment targets. We aimed to identify differences in contractile properties and physical fitness between populations, and examine associations with perceived fatigue. We pooled data on perceived fatigue, physical fitness, and contractile properties from six studies, including a control group (n = 90), cancer survivors (n = 27), patients with chronic obstructive pulmonary disease (COPD; n = 16), chronic myeloid leukemia (CML; n = 20), and statin users (n = 64). We evaluated differences between populations, and associations of contractile properties and physical fitness with perceived fatigue. Compared with the control group, we found differences in contractile properties of patients with COPD (larger muscle force decline: β = -10.5%, 95% CI = -16.7; -4.2, increase in early relaxation time (Rt): β = 84.4%, 95% CI = 51.7; 117.0, increase in half Rt: β = 83.1%, 95% CI = 45.5; 120.7, muscle force rise (MFR): β = 0.2%/ms, 95% CI = 0.1; 0.3, and decrease in MFR: β = -24.3%, 95% CI = -35.7; -13.0) and statin users (early Rt: β = -5.4 ms, 95% CI = -10.0; -0.8, increase in early Rt: β = 19.8%, 95% CI = 2.5; 37.1). Associations between contractile properties and perceived fatigue varied across populations. Longer relaxation times were associated with higher perceived fatigue in hemato-oncological populations. To conclude, contractile properties were impaired in patients with COPD and statin users. Associations between contractile properties and perceived fatigue varied across populations. In hemato-oncological populations, impaired muscle relaxation was associated with higher perceived fatigue.
了解肌肉收缩特性、身体素质及其与感知疲劳的关联，可能有助于深入了解诱发疲劳的机制和治疗靶点。我们旨在确定不同人群在收缩特性和身体素质方面的差异，并研究它们与感知疲劳的关联。我们汇总了六项研究中关于感知疲劳、身体素质和收缩特性的数据，包括一个对照组（n = 90）、癌症幸存者（n = 27）、慢性阻塞性肺疾病（COPD；n = 16）患者、慢性粒细胞白血病（CML；n = 20）患者以及他汀类药物使用者（n = 64）。我们评估了不同人群之间的差异，以及收缩特性和身体素质与感知疲劳的关联。与对照组相比，我们发现COPD患者的收缩特性存在差异（肌肉力量下降幅度更大：β = -10.5%，95%CI = -16.7；-4.2，早期松弛时间（Rt）增加：β = 84.4%，95%CI = 51.7；117.0，半Rt增加：β = 83.1%，95%CI = 45.5；120.7，肌肉力量上升（MFR）：β = 0.2%/ms，95%CI = 0.1；0.3，以及MFR下降：β = -24.3%，95%CI = -35.7；-13.0）和他汀类药物使用者（早期Rt：β = -5.4 ms，95%CI = -10.0；-0.8，早期Rt增加：β = 19.8%，95%CI = 2.5；37.1）。收缩特性与感知疲劳之间的关联因人群而异。在血液肿瘤人群中，较长的松弛时间与较高的感知疲劳相关。总之，COPD患者和他汀类药物使用者的收缩特性受损。收缩特性与感知疲劳之间的关联因人群而异。在血液肿瘤人群中，肌肉松弛受损与较高的感知疲劳相关。
