Lv Wen, Guan Qiongfeng, Hu Xingyue, Chen Jiaqi, Jiang Hong, Zhang Lisan, Fan Weinv
Department of Neurology, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, China.
Department of Neurology, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, China; Department of Neurology, Ningbo No.2 Hospital, Ningbo, China.
Neurosci Lett. 2017 Sep 14;657:211-214. doi: 10.1016/j.neulet.2017.08.021. Epub 2017 Aug 12.
Parkinson's disease (PD) is a common neurodegenerative disease characterized by dopaminergic neuronal loss. The underlying cause of PD is unknown.
To assess the clinical relevance of vestibular-ocular reflex (VOR) gain in patients with PD, especially those in the early stages.
Sixty-three PD patients and 56 control healthy individuals were enrolled in this study between Mar 2015 and Aug 2015. VOR gains were determined by video head impulse test (vHIT) device. Statistical analysis was performed to assess the difference in VOR gains between PD patients and normal people. The relationship of VOR gain with age, duration and severity of disease was also assessed.
In the control group, average VOR gain was 0.98±0.09 on the left side and 0.99±0.16 on the right side. No statistically significant difference was observed between the two sides in the control group (P>0.05). In the PD group, average VOR gain was 1.20±0.22 on the left side and 1.23±0.23 on the right side. No statistically significant difference was observed between the two sides in the PD group (P>0.05). There was a significant difference in VOR gain between the PD (both in early and mid-late stages) and the control group (P<0.05). A weak correlation was observed between VOR gain and the motor Unified Parkinson Disease Rating Scale score. No correlation of VOR gain with age, duration of disease or the Hoehn and Yahr Scale score was observed. VOR gains in PD patients were found to be higher than normal, especially in the early stages of the disease.
vHIT is a potential tool to determine the VOR gain in PD patients and may help detect PD at an early stage.
帕金森病（PD）是一种常见的神经退行性疾病，其特征为多巴胺能神经元丧失。PD的潜在病因尚不清楚。
评估帕金森病患者，尤其是早期患者前庭眼反射（VOR）增益的临床相关性。
2015年3月至2015年8月，本研究纳入了63例帕金森病患者和56名健康对照者。通过视频头脉冲试验（vHIT）设备测定VOR增益。进行统计分析以评估帕金森病患者与正常人之间VOR增益的差异。还评估了VOR增益与年龄、病程和疾病严重程度的关系。
在对照组中，左侧平均VOR增益为0.98±0.09，右侧为0.99±0.16。对照组两侧之间未观察到统计学显著差异（P>0.05）。在帕金森病组中，左侧平均VOR增益为1.20±0.22，右侧为1.23±0.23。帕金森病组两侧之间未观察到统计学显著差异（P>0.05）。帕金森病组（早期和中晚期）与对照组之间的VOR增益存在显著差异（P<0.05）。观察到VOR增益与运动性统一帕金森病评定量表评分之间存在弱相关性。未观察到VOR增益与年龄、病程或霍恩和雅尔分级量表评分之间的相关性。发现帕金森病患者的VOR增益高于正常水平，尤其是在疾病早期。
vHIT是一种测定帕金森病患者VOR增益的潜在工具，可能有助于早期检测帕金森病。
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