Petel Arthur, Jacob Deborah, Aubonnet Romain, Frismand Solène, Petersen Hannes, Gargiulo Paolo, Perrin Philippe
EA 3450 DevAH - Development, Adaptation and Handicap, Faculty of Medicine, University of Lorraine, Vandoeuvre-lès-Nancy.
Institute of Biomedical and Neural Engineering, Reykjavik University, Reykjavik.
Eur J Transl Myol. 2022 Dec 1;32(4):10884. doi: 10.4081/ejtm.2022.10884.
Postural instability and loss of vestibular and somatosensory acuity can be part of the signs encountered in Parkinson's Disease (PD). Visual dependency is described in PD. These modifications of sensory input hierarchy are predictors of motion sickness (MS). The aim of this study was to assess MS susceptibility and effects of real induced MS in posture. 63 PD patients, whose medication levels (levodopa) reflected the pathology were evaluated, and 27 healthy controls, filled a MS questionnaire; 9 PD patients and 43 healthy controls were assessed by posturography using virtual reality. Drug amount predicted visual MS (p=0.01), but not real induced MS susceptibility. PD patients did not experience postural instability in virtual reality, contrary to healthy controls. Since PD patients do not seem to feel vestibular stimulated MS, they may not rely on vestibular and somatosensory inputs during the stimulation. However, they feel visually induced MS more with increased levodopa drug effect. Levodopa amount can increase visual dependency. The strongest MS predictors must be studied in PD to better understand the effect of visual stimulation and its absence in vestibular stimulation.
姿势不稳以及前庭和本体感觉敏锐度丧失可能是帕金森病（PD）的部分症状。帕金森病中存在视觉依赖现象。这些感觉输入层级的改变是晕动病（MS）的预测指标。本研究的目的是评估晕动病易感性以及实际诱发的晕动病对姿势的影响。对63名药物水平（左旋多巴）反映病情的帕金森病患者和27名健康对照者进行了评估，他们填写了晕动病问卷；9名帕金森病患者和43名健康对照者通过虚拟现实姿势描记法进行了评估。药物剂量可预测视觉性晕动病（p=0.01），但不能预测实际诱发的晕动病易感性。与健康对照者相反，帕金森病患者在虚拟现实中未出现姿势不稳。由于帕金森病患者似乎不会感受到前庭刺激诱发的晕动病，他们在刺激过程中可能不依赖前庭和本体感觉输入。然而，随着左旋多巴药物效果增强，他们会更易感受到视觉诱发的晕动病。左旋多巴剂量会增加视觉依赖。必须对帕金森病中最强的晕动病预测指标进行研究，以更好地理解视觉刺激的作用以及前庭刺激中视觉刺激缺失的影响。
