Zhang Lei, Zhang Na, Wu Jun, Liu Xin, Chung Yiu-Cho
Paul C. Lauterbur Research Center for Biomedical Imaging, Shenzhen key laboratory for MRI, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China.
Department of Neurology, Beijing University Shenzhen Hospital, Shenzhen, China.
Magn Reson Imaging. 2017 Dec;44:65-71. doi: 10.1016/j.mri.2017.08.004. Epub 2017 Aug 12.
To develop a technique for three dimensional (3D) high resolution joint imaging of intracranial and extracranial arterial walls with improved cerebrospinal fluid (CSF) suppression and good blood suppression based on T1 weighted sampling perfection with application optimized contrast using different angle evolutions (T1w-SPACE) and to compare this technique (hereafter, iSPACE) with alternating with nutation for tailored excitation (DANTE) prepared SPACE sequence (DANTE-SPACE) for their CSF suppression performance around the mid cerebral arteries (MCA) and blood suppression at carotid arteries.
Eight volunteers and twelve patients were prospectively recruited in this institutional review board approved study. A custom designed 32-channel coil set covering the intracranial and extracranial arteries was used for signal reception. Imaging was performed in each subject using DANTE-SPACE and iSPACE. Signal-to-noise ratios (SNR) of the vessel walls at the MCA and carotid arteries, and contrast-to-noise ratios (CNR) between vessel wall and CSF at the MCA and between vessel wall and lumen at carotid arteries from the two sequences were compared.
In volunteers, contrast between CSF and white matter (surrogate for vessel wall signal) at the M2 segments in iSPACE was 67.9% higher than in DANTE-SPACE. At the carotid region, the SNR of vessel wall in iSPACE was 11.6% higher than DANTE-SPACE while the CNR in iSPACE was 13% higher than DANTE-SPACE. In patients, images with 0.6mm isotropic resolution were obtained in 7.5min. iSPACE showed 70.9% improvement in CNR between plaque and CSF at the M2 segments compared to DANTE-SPACE.
Simultaneous extracranial and intracranial arterial wall imaging using iSPACE improved CSF suppression significantly at the M2 segment of MCA while blood suppression was comparable to DANTE-SPACE. The technique achieved 3D images with 0.6mm isotropic spatial resolution and took 7.5min using a custom made coil set. Using this technique, intracranial plaque visualization was improved with no observable image SNR degradation.
基于使用不同角度演化的T1加权采样完美与应用优化对比（T1w-SPACE），开发一种用于颅内和颅外动脉壁三维（3D）高分辨率联合成像的技术，该技术具有改善的脑脊液（CSF）抑制和良好的血液抑制效果，并将该技术（以下简称iSPACE）与用于量身定制激发的交替旋转（DANTE）准备的SPACE序列（DANTE-SPACE）在大脑中动脉（MCA）周围的CSF抑制性能以及颈动脉处的血液抑制方面进行比较。
在这项经机构审查委员会批准的研究中，前瞻性招募了8名志愿者和12名患者。使用定制设计的覆盖颅内和颅外动脉的32通道线圈组进行信号接收。对每个受试者使用DANTE-SPACE和iSPACE进行成像。比较了两个序列在MCA和颈动脉处血管壁的信噪比（SNR），以及在MCA处血管壁与CSF之间以及颈动脉处血管壁与管腔之间的对比噪声比（CNR）。
在志愿者中，iSPACE中M2节段的CSF与白质（血管壁信号替代物）之间的对比度比DANTE-SPACE高67.9%。在颈动脉区域，iSPACE中血管壁的SNR比DANTE-SPACE高11.6%，而iSPACE中的CNR比DANTE-SPACE高13%。在患者中，7.5分钟内获得了各向同性分辨率为0.6mm的图像。与DANTE-SPACE相比，iSPACE在M2节段的斑块与CSF之间的CNR提高了70.9%。
使用iSPACE同时进行颅外和颅内动脉壁成像在MCA的M2节段显著改善了CSF抑制，而血液抑制与DANTE-SPACE相当。该技术使用定制线圈组实现了各向同性空间分辨率为0.6mm的3D图像，耗时7.5分钟。使用该技术，颅内斑块可视化得到改善，且未观察到图像SNR下降。
