PBP4 通过改变功能介导β-内酰胺类耐药性。
PBP4 Mediates β-Lactam Resistance by Altered Function.
机构信息
Division of HIV/AIDS, Infectious Diseases and Global Health, Department of Medicine, University of California, San Francisco, San Francisco General Hospital, San Francisco, California, USA
Public Health Research Institute Tuberculosis Center, New Jersey Medical School, Rutgers University, Newark, New Jersey, USA.
出版信息
Antimicrob Agents Chemother. 2017 Oct 24;61(11). doi: 10.1128/AAC.00932-17. Print 2017 Nov.
Abstract
Penicillin binding protein 4 (PBP4) can provide high-level β-lactam resistance in A series of missense and promoter mutations associated with were detected in strains that displayed high-level resistance. We show here that the missense mutations facilitate the β-lactam resistance mediated by PBP4 and the promoter mutations lead to overexpression of Our results also suggest a cooperative interplay among PBPs for β-lactam resistance.
摘要
青霉素结合蛋白 4（PBP4）可提供高水平的β-内酰胺耐药性，与高水平耐药相关的一系列错义和启动子突变在菌株中被检测到。我们在这里表明，错义突变促进了 PBP4 介导的β-内酰胺耐药性，启动子突变导致 的过度表达。我们的结果还表明 PBPs 之间存在协同作用，以产生β-内酰胺耐药性。
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