Zhang Yi, Heo Hye-Young, Jiang Shanshan, Bottomley Paul A, Zhou Jinyuan
Division of MR Research, Department of Radiology, Johns Hopkins University, Baltimore, MD, United States.
F. M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, United States.
Proc Int Soc Magn Reson Med Sci Meet Exhib Int Soc Magn Reson Med Sci Meet Exhib. 2017 Apr;25.
The clinical use of amide proton transfer (APT) imaging is hindered by long scan times. Accuracy generally limits the use of conventional sensitivity encoding (SENSE) methods in APT, to an acceleration factor of 2. A novel variably-accelerated sensitivity encoding (vSENSE) method can provide more accurate results and therefore substantially higher overall acceleration factors than conventional SENSE. Here, vSENSE is further developed to eliminate the requirement that one fully-sampled APT frame be acquired, and extended to three dimensions (3D). Furthermore, we combine vSENSE with parallel transmit saturation, and apply it proactively to three normal volunteers and eleven patients with brain tumors.
酰胺质子转移（APT）成像的临床应用因扫描时间长而受到阻碍。在APT中，准确性通常将传统灵敏度编码（SENSE）方法的应用限制在加速因子为2。一种新型可变加速灵敏度编码（vSENSE）方法可以提供更准确的结果，因此总体加速因子比传统SENSE高得多。在此，vSENSE得到进一步发展，以消除获取一帧全采样APT图像的要求，并扩展到三维（3D）。此外，我们将vSENSE与并行发射饱和相结合，并将其主动应用于三名正常志愿者和十一名脑肿瘤患者。
