Togao Osamu, Hiwatashi Akio, Keupp Jochen, Yamashita Koji, Kikuchi Kazufumi, Yoshiura Takashi, Suzuki Yuriko, Kruiskamp Marijn J, Sagiyama Koji, Takahashi Masaya, Honda Hiroshi
Department of Clinical Radiology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
Philips Research Europe, Hamburg, Germany.
J Magn Reson Imaging. 2015 Nov;42(5):1346-53. doi: 10.1002/jmri.24895. Epub 2015 Mar 30.
To evaluate the reproducibility of amide proton transfer (APT) imaging of brain tumors using a parallel transmission-based technique.
Thirteen patients with brain tumors (four low-grade gliomas, three glioblastoma multiforme, five meningiomas, and one malignant lymphoma) were included in the study. APT imaging was conducted at 3T using a 2-channel parallel transmission scheme with a saturation time of 2 seconds and B1 amplitude of 2 μT. A 2D fast spin-echo sequence with driven-equilibrium refocusing was used for imaging. Z-spectra were obtained at 25 frequency offsets from -6 to +6 ppm (step 0.5 ppm). A point-by-point B0 correction was performed with a B0 map. A scan-rescan reproducibility test was performed in two sessions on separate days for each patient. The interval between the two sessions was 4.8 ± 3.5 days. Regions-of-interest (ROIs) were placed to include the whole tumor for each case. A mean and 90-percentile value of APT signal for the whole tumor histogram was calculated for each session. The between-session and within-session reproducibility was evaluated using linear regression analysis, intraclass correlation coefficient (ICC), and a Bland-Altman plot.
The mean and 90-percentile values of the APT signal for whole tumor ROI showed excellent agreements between the two sessions, with R(2) of 0.91 and 0.96 in the linear regression analysis and ICC of 0.95 and 0.97, respectively.
Parallel transmission-based APT imaging of brain tumors showed good reproducibility.
使用基于并行传输的技术评估脑肿瘤酰胺质子转移（APT）成像的可重复性。
本研究纳入了13例脑肿瘤患者（4例低级别胶质瘤、3例多形性胶质母细胞瘤、5例脑膜瘤和1例恶性淋巴瘤）。在3T条件下采用2通道并行传输方案进行APT成像，饱和时间为2秒，B1幅度为2μT。使用具有驱动平衡重聚焦的二维快速自旋回波序列进行成像。在-6至+6 ppm（步长0.5 ppm）的25个频率偏移处获取Z谱。使用B0图进行逐点B0校正。对每位患者在不同日期分两次进行扫描-重复扫描可重复性测试。两次测试之间的间隔为4.8±3.5天。针对每个病例放置感兴趣区域（ROI）以包含整个肿瘤。计算每次测试中整个肿瘤直方图的APT信号的平均值和第90百分位数。使用线性回归分析、组内相关系数（ICC）和Bland-Altman图评估两次测试之间和每次测试内部的可重复性。
整个肿瘤ROI的APT信号的平均值和第90百分位数在两次测试之间显示出极好的一致性，线性回归分析中的R²分别为0.91和0.96，ICC分别为0.95和0.97。
基于并行传输的脑肿瘤APT成像显示出良好的可重复性。
