Kyoto University Graduate School of Medicine, Department of Diagnostic Imaging and Nuclear Medicine, Kyoto, Japan.
Kyoto University Graduate School of Medicine, Human Brain Research Center, Kyoto, Japan.
J Magn Reson Imaging. 2017 Sep;46(3):732-739. doi: 10.1002/jmri.25597. Epub 2017 Mar 2.
To explore the relationship among parameters of magnetic resonance spectroscopy (MRS) and amide proton transfer (APT) imaging, and to assess the diagnostic performance of MRS and APT imaging for grading brain tumors in comparison with contrast enhancement of conventional MRI for preoperative grading in patients with brain tumor.
Institutional Review Board approval and written informed consent were obtained. Forty-one patients with suspected brain tumors were enrolled in the study. Single-voxel MRS and 2D APT imaging of the same slice level were conducted using a 3T MRI scanner. Positive or negative contrast enhancement on T -weighted images was assessed by two neuroradiologists. Correlations among metabolite concentrations, metabolite ratios, and calculated histogram parameters, including mean APT (APT ) and the 90th percentile of APT (APT ) were assessed using Spearman's correlation coefficient. Diagnostic performance was evaluated with receiver operating characteristic (ROC) curve analysis for contrast enhancement and MRS and APT imaging. Values of P < 0.05 were considered statistically significant.
Positive correlations with statistical significance were found between total concentration of choline (Cho) and APT (r = 0.49), and between Cho/creatine (Cr) and APT (r = 0.65) as well as APT (r = 0.49). A negative correlation with statistical significance was observed between NAA/Cr and APT (r = -0.52). According to ROC curves, Cho/Cr, APT , APT , demonstrated higher area under the curve (AUC) values than that of contrast enhancement in grading gliomas.
Significant correlations were observed between metabolite concentrations and ratios on MRS and APT values. MRS and APT imaging showed comparable diagnostic capability for grading brain tumors, suggesting that both MRS and APT imaging offer potential for quantitatively assessing similar biological characteristics in brain tumors on noncontrast MRI.
2 Technical Efficacy: Stage 2 J. MAGN. RESON. IMAGING 2017;46:732-739.
探讨磁共振波谱（MRS）和酰胺质子转移（APT）成像参数之间的关系，并评估 MRS 和 APT 成像在术前分级中的诊断性能，与常规 MRI 增强对比在脑肿瘤患者中的分级相比。
获得机构审查委员会批准和书面知情同意。对 41 例疑似脑肿瘤患者进行了研究。使用 3T MRI 扫描仪对同一切片水平进行单体素 MRS 和 2D APT 成像。两位神经放射科医生评估 T 加权图像上的阳性或阴性对比增强。使用 Spearman 相关系数评估代谢物浓度、代谢物比和计算的直方图参数（包括平均 APT（APT ）和 APT 的第 90 个百分位数（APT ））之间的相关性。使用接收者操作特征（ROC）曲线分析对对比增强和 MRS 和 APT 成像进行诊断性能评估。P 值<0.05 被认为具有统计学意义。
Cho 与 APT（r=0.49）和 Cho/Cr 与 APT（r=0.65）以及 APT（r=0.49）之间存在统计学显著的正相关。NAA/Cr 与 APT（r=-0.52）之间存在统计学显著的负相关。根据 ROC 曲线，Cho/Cr、APT 、APT 、在分级胶质瘤方面的曲线下面积（AUC）值高于对比增强。
MRS 和 APT 上的代谢物浓度和比值之间存在显著相关性。MRS 和 APT 成像在分级脑肿瘤方面具有相当的诊断能力，这表明 MRS 和 APT 成像都有可能在非对比 MRI 上定量评估脑肿瘤的相似生物学特征。
2 技术功效：2 期 J. MAGN. RESON. IMAGING 2017;46:732-739.
