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辛夷清肺汤体外抑制生物膜形成。

Shin'iseihaito (Xinyiqingfeitang) Suppresses the Biofilm Formation of In Vitro.

作者信息

Minami Masaaki, Konishi Toru, Takase Hiroshi, Makino Toshiaki

机构信息

Department of Bacteriology, Graduate School of Medical Sciences, Nagoya City University, 1 Kawasumi, Mizuho-ku, Nagoya, Japan.

Department of Pharmacognosy, Graduate School of Pharmaceutical Sciences, Nagoya City University, 3-1 Tanabe-Dori, Mizuho-ku, Nagoya, Japan.

出版信息

Biomed Res Int. 2017;2017:4575709. doi: 10.1155/2017/4575709. Epub 2017 Apr 16.

DOI:10.1155/2017/4575709
PMID:28567419
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5439249/
Abstract

() is the important pathogen that causes otolaryngeal diseases such as sinusitis. frequently forms the biofilm to prevent severe circumstances such as antimicrobial agents. Shin'iseihaito (xinyiqingfeitang) is a formula of Japanese traditional Kampo medicine that has 9 crude drugs and provides the medicinal usage for sinusitis. The objective of the present study is to reveal the mechanism of antibiofilm activity by Shin'iseihaito extract (SSHT). SSHT significantly inhibited the formation of biofilm from ATCC 49619 in dose- and time-dependent manners. SSHT also significantly suppressed the biofilm formation by other five different cps types of clinical isolates. We found that the extracts of 8 out of 9 components in Shin'iseihaito had the inhibitory effects of biofilm formation, and the extract of the root of had the strongest effect among the ingredients of Shin'iseihaito. We found that the capsule of SSHT-treated was significantly thinner than that of the untreated group and that SSHT reduced the hydrophobicity of bacterial cell surface. Our results suggest that Shin'iseihaito may be a useful agent for the treatment of -induced sinusitis because of the inhibition of biofilm formation of .

摘要

（）是导致鼻窦炎等耳鼻喉疾病的重要病原体。它经常形成生物膜以抵御抗菌剂等严峻情况。辛夷清肺汤是一种日本传统汉方药物配方，含有9种药材，用于治疗鼻窦炎。本研究的目的是揭示辛夷清肺汤提取物（SSHT）的抗生物膜活性机制。SSHT以剂量和时间依赖性方式显著抑制ATCC 49619生物膜的形成。SSHT还显著抑制了其他五种不同cps类型临床分离株的生物膜形成。我们发现辛夷清肺汤中9种成分中的8种提取物具有抑制生物膜形成的作用，其中辛夷清肺汤中根部提取物的效果最强。我们发现SSHT处理组的荚膜明显比未处理组薄，并且SSHT降低了细菌细胞表面的疏水性。我们的结果表明，由于辛夷清肺汤抑制了（）生物膜的形成，它可能是治疗（）引起的鼻窦炎的有用药物。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bd6c/5439249/7e954bda5c36/BMRI2017-4575709.007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bd6c/5439249/13812c42055c/BMRI2017-4575709.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bd6c/5439249/658bed9ac2c4/BMRI2017-4575709.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bd6c/5439249/660921b9675e/BMRI2017-4575709.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bd6c/5439249/dcb76431152f/BMRI2017-4575709.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bd6c/5439249/602d026baf33/BMRI2017-4575709.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bd6c/5439249/aea24d7f9b00/BMRI2017-4575709.006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bd6c/5439249/7e954bda5c36/BMRI2017-4575709.007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bd6c/5439249/13812c42055c/BMRI2017-4575709.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bd6c/5439249/658bed9ac2c4/BMRI2017-4575709.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bd6c/5439249/660921b9675e/BMRI2017-4575709.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bd6c/5439249/dcb76431152f/BMRI2017-4575709.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bd6c/5439249/602d026baf33/BMRI2017-4575709.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bd6c/5439249/aea24d7f9b00/BMRI2017-4575709.006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bd6c/5439249/7e954bda5c36/BMRI2017-4575709.007.jpg

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