• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

采用自体髂骨移植及纳米骨/骨髓抽吸物的高位颈椎融合率高。

High posterior cervical fusion rates with iliac autograft and Nanoss/bone marrow aspirate.

作者信息

Epstein Nancy E

机构信息

Chief of Neurosurgical Spine/Education, NYU Winthrop Hospital, Mineola, New York, USA.

出版信息

Surg Neurol Int. 2017 Jul 20;8:152. doi: 10.4103/sni.sni_241_17. eCollection 2017.

DOI:10.4103/sni.sni_241_17
PMID:28808601
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5535513/
Abstract

BACKGROUND

Patients with severe cervical multilevel stenosis and an adequate lordotic curvature often undergo multilevel laminectomies with posterior instrumented fusions. Although the "gold standard" for the fusion mass remains iliac crest autograft, many require additional volume provided by bone graft expanders. Here, we studied the fusion rates for 32 patients undergoing multilevel cervical laminectomy and vertex/rod/eyelet/titanium cable fusions utilizing lamina/iliac autograft and the bone graft expander Nanoss (RTI Surgical, Alachua, FL, USA) with autogenous bone marrow aspirate (BMA).

METHODS

Thirty-two patients, averaging 63.0 years of age, presented with severe cervical myeloradiculopathy (average Nurick Grade 4.4). Magnetic resonance (MR) studies documented 2-3-level high intrinsic cord signals, whereas computed tomography (CT) scans confirmed marked stenosis and ossification of the posterior longitudinal ligament (OPLL)/ossification of the yellow ligament (OYL). Patients underwent multilevel lamnectomies/instrumented fusions, and were followed up for an average of 2.7 years.

RESULTS

Multilevel laminectomies (2.8 levels) and average 7.8-level vertex/rod/eyelet/cable fusions were performed utilizing lamina/iliac crest autograft and Nanoss/BMA. Fusion was confirmed on X-ray/CT studies an average of 4.7 months postoperatively in 31 of 32 patients (97%); there was just one pseudarthrosis requiring secondary surgery. The only other complication was a delayed transient C5 palsy that fully resolved in 6 postoperative months.

CONCLUSIONS

Thirty-two severely myelopathic underwent 2.8-level cervical laminectomies/7.8 level fusions utilizing lamina/iliac autograft and Nanoss/BMA. Fusion was documented on both dynamic X-ray and CT studies in 31 of 32 (97%) patients an average of 4.7 months postoperatively. Nanoss/BMA appears to be a safe and effective bone graft expander that can be utilized for posterior cervical fusions.

摘要

背景

患有严重颈椎多节段狭窄且颈椎生理前凸曲度正常的患者，常需接受多节段椎板切除术并进行后路器械辅助融合术。尽管融合块的“金标准”仍是髂嵴自体骨移植，但许多患者还需要骨移植扩张器来提供额外的骨量。在此，我们研究了32例接受多节段颈椎椎板切除术并采用椎板/髂骨自体骨、骨移植扩张器Nanoss（美国佛罗里达州阿拉楚阿市RTI Surgical公司生产）及自体骨髓抽吸物（BMA）进行顶点/棒/孔眼/钛缆融合术患者的融合率。

方法

32例患者，平均年龄63.0岁，均患有严重的颈椎脊髓神经根病（平均Nurick分级为4.4级）。磁共振（MR）检查显示2 - 3节段脊髓内信号增强，而计算机断层扫描（CT）扫描证实存在明显的椎管狭窄、后纵韧带骨化（OPLL）/黄韧带骨化（OYL）。患者接受了多节段椎板切除术/器械辅助融合术，并平均随访2.7年。

结果

采用椎板/髂嵴自体骨及Nanoss/BMA进行了平均2.8节段的多节段椎板切除术和平均7.8节段的顶点/棒/孔眼/钛缆融合术。32例患者中有31例（97%）在术后平均4.7个月时经X线/CT检查证实融合；仅1例出现假关节，需再次手术。唯一的其他并发症是延迟性短暂性C₅麻痹，在术后6个月完全恢复。

结论

32例严重脊髓病患者接受了平均2.8节段的颈椎椎板切除术/平均7.8节段的融合术，采用椎板/髂骨自体骨及Nanoss/BMA。32例患者中有31例（97%）在术后平均4.7个月时经动态X线和CT检查证实融合。Nanoss/BMA似乎是一种安全有效的骨移植扩张器，可用于颈椎后路融合术。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dc42/5535513/3f5c0175f521/SNI-8-152-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dc42/5535513/e500e6ffaac0/SNI-8-152-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dc42/5535513/1cf1fc6a227b/SNI-8-152-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dc42/5535513/7bc383db14db/SNI-8-152-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dc42/5535513/bd08a8c494c3/SNI-8-152-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dc42/5535513/3f5c0175f521/SNI-8-152-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dc42/5535513/e500e6ffaac0/SNI-8-152-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dc42/5535513/1cf1fc6a227b/SNI-8-152-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dc42/5535513/7bc383db14db/SNI-8-152-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dc42/5535513/bd08a8c494c3/SNI-8-152-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dc42/5535513/3f5c0175f521/SNI-8-152-g007.jpg

相似文献

1
High posterior cervical fusion rates with iliac autograft and Nanoss/bone marrow aspirate.采用自体髂骨移植及纳米骨/骨髓抽吸物的高位颈椎融合率高。
Surg Neurol Int. 2017 Jul 20;8:152. doi: 10.4103/sni.sni_241_17. eCollection 2017.
2
High lumbar noninstrumented fusion rates using lamina autograft and Nanoss/bone marrow aspirate.使用椎板自体骨移植和纳米羟基磷灰石/骨髓抽吸物的高位腰椎非器械融合率
Surg Neurol Int. 2017 Jul 20;8:153. doi: 10.4103/sni.sni_248_17. eCollection 2017.
3
Preliminary documentation of the comparable efficacy of vitoss versus NanOss bioactive as bone graft expanders for posterior cervical fusion.Vitoss与NanOss生物活性材料作为后路颈椎融合术骨移植扩张剂的疗效对比的初步文献记录。
Surg Neurol Int. 2015 May 7;6(Suppl 4):S164-71. doi: 10.4103/2152-7806.156559. eCollection 2015.
4
Preliminary study showing safety/efficacy of nanoss bioactive versus vitoss as bone graft expanders for lumbar noninstrumented fusions.初步研究表明，与Vitoss相比，Nanoss生物活性材料作为腰椎非内固定融合术的骨移植扩张材料的安全性/有效性。
Surg Neurol Int. 2015 Jun 25;6(Suppl 10):S318-22. doi: 10.4103/2152-7806.159380. eCollection 2015.
5
Efficacy of posterior cervical fusions utilizing an artificial bone graft expander, beta tricalcium phosphate.使用人工骨移植扩张器β-磷酸三钙进行颈椎后路融合术的疗效
Surg Neurol Int. 2011 Jan 31;2:15. doi: 10.4103/2152-7806.76458.
6
An argument for traditional posterior cervical fusion techniques: evidence from 35 cases.传统颈椎后路融合技术的论据：来自35例病例的证据。
Surg Neurol. 2008 Jul;70(1):45-51; discussion 51-2. doi: 10.1016/j.surneu.2007.10.023. Epub 2008 Mar 4.
7
Short Form-36 outcomes following focal 1- and 2-level cervical laminectomy with multilevel instrumented fusion.单节段和双节段颈椎后路减压并多节段器械辅助融合术后的简明健康状况调查问卷-36项结果
Surg Neurol. 2006 Sep;66(3):264-8; discussion 268. doi: 10.1016/j.surneu.2006.05.032.
8
An analysis of noninstrumented posterolateral lumbar fusions performed in predominantly geriatric patients using lamina autograft and beta tricalcium phosphate.对主要为老年患者采用椎板自体骨移植和β-磷酸三钙进行的非器械辅助腰椎后外侧融合术的分析。
Spine J. 2008 Nov-Dec;8(6):882-7. doi: 10.1016/j.spinee.2007.11.005. Epub 2008 Feb 14.
9
Posterior cervical fusion failure in three morbidly obese patients following circumferential surgery.
Surg Neurol. 2003 Sep;60(3):205-10; discussion 210. doi: 10.1016/s0090-3019(03)00295-7.
10
SF-36 outcomes and fusion rates after multilevel laminectomies and 1 and 2-level instrumented posterolateral fusions using lamina autograft and demineralized bone matrix.使用椎板自体移植和脱矿骨基质进行多级椎板切除术后以及单节段和双节段器械辅助后外侧融合术后的SF-36结果和融合率。
J Spinal Disord Tech. 2007 Apr;20(2):139-45. doi: 10.1097/01.bsd.0000211261.36120.3e.

引用本文的文献

1
Evaluation of Vertebral Function and Long-Term Quality of Life after Percutaneous Minimally Invasive Surgery in Patients with Thoracolumbar Spine Fractures.胸腰椎骨折患者经皮微创术后脊柱功能评估及长期生活质量
Comput Math Methods Med. 2022 Feb 23;2022:2723542. doi: 10.1155/2022/2723542. eCollection 2022.
2
A feasibility study of modified self-efficacy for the improvement of adverse emotions and quality of life in traumatic fracture patients.改良自我效能对改善创伤性骨折患者不良情绪及生活质量的可行性研究
Am J Transl Res. 2021 Jun 15;13(6):6507-6515. eCollection 2021.
3
Autologous Stem Cells in Cervical Spine Fusion.

本文引用的文献

1
Bone substitutes and expanders in Spine Surgery: A review of their fusion efficacies.脊柱手术中的骨替代物和扩张器：对其融合效果的综述
Int J Spine Surg. 2016 Sep 22;10:33. doi: 10.14444/3033. eCollection 2016.
2
Comparison of Two Synthetic Bone Graft Products in a Rabbit Posterolateral Fusion Model.兔后外侧融合模型中两种人工骨移植产品的比较
Iowa Orthop J. 2016;36:167-73.
3
Comparison of Silicate-Substituted Calcium Phosphate (Actifuse) with Recombinant Human Bone Morphogenetic Protein-2 (Infuse) in Posterolateral Instrumented Lumbar Fusion.
颈椎融合术中的自体干细胞
Global Spine J. 2021 Jul;11(6):950-965. doi: 10.1177/2192568220948479. Epub 2020 Sep 23.
4
Clinical and radiological outcomes of a cervical cage with integrated fixation.具有一体化固定功能的颈椎椎间融合器的临床及影像学结果
Medicine (Baltimore). 2019 Jan;98(3):e14097. doi: 10.1097/MD.0000000000014097.
5
Nursing review of cervical laminectomy and fusion.颈椎椎板切除术和融合术的护理综述
Surg Neurol Int. 2017 Dec 11;8:300. doi: 10.4103/sni.sni_243_17. eCollection 2017.
硅酸钙取代的磷酸钙（Actifuse）与重组人骨形态发生蛋白-2（Infuse）在后外侧器械化腰椎融合中的比较。
Global Spine J. 2015 Dec;5(6):471-8. doi: 10.1055/s-0035-1566230.
4
Posterolateral fusion in acute traumatic thoracolumbar fractures: a comparison of demineralized bone matrix and autologous bone graft.急性创伤性胸腰椎骨折的后外侧融合术：脱矿骨基质与自体骨移植的比较
Acta Chir Orthop Traumatol Cech. 2015;82(2):119-25.
5
Preliminary study showing safety/efficacy of nanoss bioactive versus vitoss as bone graft expanders for lumbar noninstrumented fusions.初步研究表明，与Vitoss相比，Nanoss生物活性材料作为腰椎非内固定融合术的骨移植扩张材料的安全性/有效性。
Surg Neurol Int. 2015 Jun 25;6(Suppl 10):S318-22. doi: 10.4103/2152-7806.159380. eCollection 2015.
6
Preliminary documentation of the comparable efficacy of vitoss versus NanOss bioactive as bone graft expanders for posterior cervical fusion.Vitoss与NanOss生物活性材料作为后路颈椎融合术骨移植扩张剂的疗效对比的初步文献记录。
Surg Neurol Int. 2015 May 7;6(Suppl 4):S164-71. doi: 10.4103/2152-7806.156559. eCollection 2015.
7
Bone graft and bone graft substitutes in spine surgery: current concepts and controversies.脊柱外科中的骨移植和骨移植替代物：当前的概念和争议。
J Am Acad Orthop Surg. 2013 Jan;21(1):51-60. doi: 10.5435/JAAOS-21-01-51.
8
Silicate-substituted calcium phosphate as a bone graft substitute in surgery for adolescent idiopathic scoliosis.硅取代钙磷作为青少年特发性脊柱侧凸手术中的骨移植替代物。
Eur Spine J. 2013 Mar;22 Suppl 2(Suppl 2):S185-94. doi: 10.1007/s00586-012-2485-7. Epub 2012 Sep 5.
9
Efficacy of posterior cervical fusions utilizing an artificial bone graft expander, beta tricalcium phosphate.使用人工骨移植扩张器β-磷酸三钙进行颈椎后路融合术的疗效
Surg Neurol Int. 2011 Jan 31;2:15. doi: 10.4103/2152-7806.76458.
10
An argument for traditional posterior cervical fusion techniques: evidence from 35 cases.传统颈椎后路融合技术的论据：来自35例病例的证据。
Surg Neurol. 2008 Jul;70(1):45-51; discussion 51-2. doi: 10.1016/j.surneu.2007.10.023. Epub 2008 Mar 4.