Koo So-My, Kim Yunsun, Park Chorong, Park Gun Woo, Lee MoonGyu, Won Sungho, Yang Hyeon-Jong
Division of Allergy and Respiratory Medicine, Department of Internal Medicine, Soonchunhyang University Seoul Hospital, Soonchunhyang University College of Medicine, Seoul, Republic of Korea.
SCH Biomedical Informatics Research Unit, Soonchunhyang University Seoul Hospital, Seoul, Republic of Korea.
Biomed Res Int. 2017;2017:8276190. doi: 10.1155/2017/8276190. Epub 2017 Jul 20.
The quantification of asthma medication reduction and its relation to an aggravation of asthma during pregnancy at an individual level are unclear.
We conducted a nationwide retrospective cohort study of asthmatic pregnant women in South Korea. All of the asthma medications were ranked from 1 to 4 according to the guideline-based stepwise approach. We assessed the daily sums of the ranks of the asthma medications and their association with exacerbations during three phases based on the individual's delivery date: before, during, and after pregnancy.
The study cohort included 115,169 asthmatic pregnant women who gave birth between 2011 and 2013. The subjects were clustered into four groups according to the daily rank sums of their asthma medication. Asthma medications were rapidly reduced at the beginning of the pregnancy and then slowly increased after delivery. Exacerbations were more frequent in the group with higher rank-sum values than in the group with lower values. Overall exacerbations were reduced during pregnancy compared to before or after delivery.
Asthmatic pregnant women tended to reduce their asthma medication use during pregnancy. This led to a greater number of exacerbations in a small part of the study population.
孕期哮喘药物减量的量化及其与个体哮喘病情加重之间的关系尚不清楚。
我们对韩国的哮喘孕妇进行了一项全国性回顾性队列研究。根据基于指南的逐步治疗方法，将所有哮喘药物从1到4进行排名。我们根据个体分娩日期评估了哮喘药物排名的每日总和及其在三个阶段（孕前、孕期和产后）与病情加重的关联。
研究队列包括2011年至2013年间分娩的115,169名哮喘孕妇。根据哮喘药物的每日排名总和，将受试者分为四组。哮喘药物在孕期开始时迅速减少，产后则缓慢增加。排名总和值较高的组比排名总和值较低的组病情加重更频繁。与分娩前或产后相比，孕期总体病情加重情况有所减少。
哮喘孕妇在孕期倾向于减少哮喘药物的使用。这导致在一小部分研究人群中病情加重的次数更多。
