Ratey J J, Mikkelsen E, Sorgi P, Zuckerman H S, Polakoff S, Bemporad J, Bick P, Kadish W
J Clin Psychopharmacol. 1987 Feb;7(1):35-41.
Eight consecutive cases of adults with the diagnosis of early infantile autism and who were treated with a betablocker are presented. Each had been on various and multiple drug, educational, and behavioral regimens to help control aggressive and self-abusive behavior. Most had been institutionalized from an early age, and a broad range of IQs and speech capacities are represented. Results show the betablockers to have a remarkable effect potentiating measurable diminution in previously intractable aggressive behavior and in many cases the decrease or withdrawal of their neuroleptic.
本文报告了八例被诊断为早期婴儿自闭症的成人患者,他们接受了β受体阻滞剂治疗。每例患者此前都接受过多种药物、教育和行为治疗方案,以帮助控制攻击性行为和自我伤害行为。大多数患者自幼就被送入机构照料,涵盖了广泛的智商和语言能力范围。结果显示,β受体阻滞剂具有显著效果,可使先前难以控制的攻击性行为明显减少,并且在许多情况下可减少或停用抗精神病药物。