Naja Wadih Jean, Aoun Michaelangelo Pietro
Department of Psychiatry, Lebanese University, Beirut, Lebanon.
Gharios Medical Center, Mount Lebanon Hospital, Hazmieh, Beirut, Lebanon.
Curr Psychiatry Rep. 2017 Aug 15;19(10):67. doi: 10.1007/s11920-017-0819-1.
This review aims to evaluate the most recent literature examining the oxytocin (OXT) system's role in human anxiety by surveying various fields of preclinical and clinical research supporting this role, and queries whether the OXT system might be a target for novel anxiolytics.
Evidence from the diverse body of literature presented here, from translational research, genetic and neuroimaging studies, to clinical trials of intranasal (IN) OXT reveals a positive association. In addition, some moderators (e.g., sex, specificities to cues) of OXT's anxiolytic effects can have an important influence on its outcomes, awaiting further research. Evidence for the role of OXT in regulating anxiety is undeniable. We expect that the diverse particularities of the OXT system will help broaden our understanding of anxiety and stress-related disorders. We conclude that OXT promises an enticing treatment option for human anxiety disorders especially those associated with socio-emotional dysfunctions.
本综述旨在通过调查支持催产素（OXT）系统在人类焦虑中作用的临床前和临床研究的各个领域，评估研究催产素系统在人类焦虑中作用的最新文献，并探讨催产素系统是否可能成为新型抗焦虑药物的靶点。
此处呈现的来自不同文献的证据，从转化研究、基因和神经影像学研究到鼻内（IN）催产素的临床试验，均显示出正相关。此外，催产素抗焦虑作用的一些调节因素（如性别、对线索的特异性）可对其结果产生重要影响，有待进一步研究。催产素在调节焦虑中的作用证据确凿。我们预计，催产素系统的各种特殊性将有助于拓宽我们对焦虑和应激相关障碍的理解。我们得出结论，催产素有望为人类焦虑症，尤其是那些与社会情感功能障碍相关的焦虑症提供一种诱人的治疗选择。
