Bass J J, Gluckman P D, Fairclough R J, Peterson A J, Davis S R, Carter W D
J Endocrinol. 1987 Jan;112(1):27-31. doi: 10.1677/joe.0.1120027.
The effect of immunizing against somatostatin (SRIF), with SRIF conjugated to bovine thyroglobulin, was examined in cross-bred sheep fed either cut pasture or lucerne pellets. Plasma concentrations of GH were unaffected by SRIF immunization, but were lower in pellet-fed sheep. Plasma concentrations of insulin-like growth factor I (IGF-I) increased after immunization in sheep on both diets. Pasture-fed sheep had lower plasma concentrations of IGF-I than those on pellets. Sheep showed a small increase in growth rate in response to immunization. Immunization had no effect on carcass composition and did not affect plasma concentrations of IGF-II, free fatty acids or glucose. The results show that even though SRIF immunization increases plasma concentrations of IGF-I, it does not necessarily result in a large increase in growth rate.
在以剪割牧草或苜蓿颗粒料为食的杂交绵羊中，研究了用与牛甲状腺球蛋白偶联的生长抑素（SRIF）进行免疫的效果。生长激素（GH）的血浆浓度不受SRIF免疫的影响，但在采食颗粒料的绵羊中较低。两种日粮的绵羊免疫后，胰岛素样生长因子I（IGF-I）的血浆浓度均升高。采食牧草的绵羊的IGF-I血浆浓度低于采食颗粒料的绵羊。绵羊对免疫的反应是生长速率略有增加。免疫对胴体组成没有影响，也不影响IGF-II、游离脂肪酸或葡萄糖的血浆浓度。结果表明，即使SRIF免疫会增加IGF-I的血浆浓度，但不一定会导致生长速率大幅提高。
