Bagan L, Jiménez Y, Leopoldo M, Rubert A, Bagan J
Service of Stomatology and Maxillofacial Surgery, Avda/ Tres Cruces s/n, 46014 Valencia, Spain,
Med Oral Patol Oral Cir Bucal. 2017 Sep 1;22(5):e542-e547. doi: 10.4317/medoral.22128.
We determined whether serum levels of Receptor Activator for Nuclear Factor κ B Ligand (RANKL), Osteoprotegerin (OPG), and the RANKL/OPG ratio could be useful biomarkers for the severity of oral lesions in bisphosphonate-related osteonecrosis of the jaw (BRONJ).
A case-control study in which Group 1 consisted of 41 patients with BRONJ due to intravenous bisphosphonates, and Group 2 consisted of 44 healthy control cases. The plasma levels of RANKL and OPG were analyzed by an ELISA assay. The OPG/RANKL ratio was also calculated. We determined if the mean serum values differed among the different stages of BRONJ.
Serum levels of RANKL were lower in Group 1 than in Group 2 (p =0.01), and serum levels of OPG were higher in patients with BRONJ than in the controls (p =0.006). The ratio of RANKL/OPG was greater in the controls than in Group 1 (p >0.01). There were no significant differences in the serum levels of RANKL and OPG among the different stages of osteonecrosis (p >0.05).
Serum levels of RANKL and OPG, and the RANKL/OPG ratio were not valuable biomarkers for determining the severity of oral lesions in patients with BRONJ.
我们确定了血清中核因子κB受体激活剂配体（RANKL）、骨保护素（OPG）水平以及RANKL/OPG比值是否可作为双膦酸盐相关颌骨骨坏死（BRONJ）口腔病变严重程度的有用生物标志物。
一项病例对照研究，其中第1组由41例因静脉注射双膦酸盐导致BRONJ的患者组成，第2组由44例健康对照病例组成。采用酶联免疫吸附测定法分析血浆中RANKL和OPG的水平。还计算了OPG/RANKL比值。我们确定了BRONJ不同阶段的血清平均值是否存在差异。
第1组血清RANKL水平低于第2组（p =0.01），BRONJ患者血清OPG水平高于对照组（p =0.006）。对照组的RANKL/OPG比值高于第1组（p >0.01）。骨坏死不同阶段的血清RANKL和OPG水平无显著差异（p >0.05）。
血清RANKL和OPG水平以及RANKL/OPG比值并非确定BRONJ患者口腔病变严重程度的有价值生物标志物。
