超声介导溶质透过聚合物屏障。

Ultrasonically mediated solute permeation through polymer barriers.

作者信息

Julian T N, Zentner G M

出版信息

J Pharm Pharmacol. 1986 Dec;38(12):871-7. doi: 10.1111/j.2042-7158.1986.tb03374.x.

DOI:10.1111/j.2042-7158.1986.tb03374.x

Abstract

The effects of ultrasound on the permeation of benzoic acid through polydimethylsiloxane, and hydrocortisone through cellulose was investigated. Ultrasonic irradiation resulted in a 23% increase in the permeability coefficient of hydrocortisone in a cellulose film. A 14% increase in permeability coefficient was observed for benzoic acid in a polydimethylsiloxane film. The effects of ultrasound on stagnant aqueous diffusion layers, membrane-solution interfacial temperature, membrane integrity, and diffusant stability were investigated. These factors were not responsible for the observed increases in permeability.

摘要

研究了超声波对苯甲酸透过聚二甲基硅氧烷以及氢化可的松透过纤维素的渗透作用。超声辐照使氢化可的松在纤维素膜中的渗透系数提高了23%。聚二甲基硅氧烷膜中苯甲酸的渗透系数提高了14%。研究了超声波对停滞水扩散层、膜-溶液界面温度、膜完整性和扩散剂稳定性的影响。观察到的渗透率增加并非由这些因素导致。