Department of Preventive Medicine and Public Health, Catholic Kwandong University College of Medicine, Gangneung, 25601, Republic of Korea.
Institute for Clinical and Translational Research, Catholic Kwandong University College of Medicine, Gangneung, 20601, Republic of Korea.
Sci Rep. 2017 Aug 15;7(1):8194. doi: 10.1038/s41598-017-08498-6.
The association of fasting glucose with the risk of death according to sex and age remains unclear, and insufficient information is available on sex- and age-specific glucose concentrations within ethnic groups. This study analyzed a sample of 12,455,361 Korean adults who participated in health examinations during 2001-2004, and were followed up until 2013. Men had 3.0 mg/dL (0.167 mmol/L) higher mean glucose concentrations than women (94.7 vs. 91.7 mg/dL), although women over 73 years had higher levels. For glucose levels of 100-199 mg/dL, each 18 mg/dL (1 mmol/L) increase in fasting glucose increased mortality by 13% (HR = 1.13, [95% CI 1.12 to 1.13], p < 0.001). In individuals with fasting glucose levels of 100-125 mg/dL, each 18 mg/dL increase in fasting glucose was associated with a 30% increase in the risk for mortality (1.30, [1.18 to 1.43]) in those aged 18-34 years, a 32% increase (1.32, [1.26 to 1.39]) in those aged 35-44 years, and a 10% increase (1.10, [1.02 to 1.19]) in those aged 75-99 years. The fasting glucose levels associated with the lowest mortality were 80-94 mg/dL regardless of sex and age. Prediabetes (100-125 mg/dL) was associated with higher mortality. The associations of hyperglycemia with mortality were stronger at younger ages.
空腹血糖与死亡风险的相关性在性别和年龄方面尚不清楚，并且在不同种族群体中，关于性别和年龄特异性血糖浓度的信息还不够充分。本研究分析了 2001-2004 年期间参加健康检查的 12455361 名韩国成年人的样本，并随访至 2013 年。男性的平均血糖浓度比女性高 3.0mg/dL（0.167mmol/L）（94.7 与 91.7mg/dL），尽管 73 岁以上的女性血糖水平更高。对于 100-199mg/dL 的血糖水平，空腹血糖每升高 18mg/dL（1mmol/L），死亡率增加 13%（HR=1.13，[95%CI 1.12 至 1.13]，p<0.001）。在空腹血糖水平为 100-125mg/dL 的个体中，空腹血糖每升高 18mg/dL，与 18-34 岁人群死亡率增加 30%（1.30，[1.18 至 1.43]）、35-44 岁人群死亡率增加 32%（1.32，[1.26 至 1.39]）和 75-99 岁人群死亡率增加 10%（1.10，[1.02 至 1.19]）相关。无论性别和年龄如何，与最低死亡率相关的空腹血糖水平均为 80-94mg/dL。糖尿病前期（100-125mg/dL）与更高的死亡率相关。高血糖与死亡率的关联在较年轻时更强。
