School of Public Health, Zhejiang Chinese Medical University, Hangzhou, Zhejiang Province, China.
Quzhou Center for Disease Control and Prevention, Quzhou, Zhejiang Province, China.
PLoS One. 2024 Nov 19;19(11):e0311150. doi: 10.1371/journal.pone.0311150. eCollection 2024.
Despite a growing body of research indicating a link between fasting glucose levels and mortality, the relationship between fasting glucose and all-cause and cancer mortality remains inconsistent. In this study, we used Cox regression and restricted cubic spline models to analyze the association and dose-response relationship between fasting plasma glucose levels and all-cause and cancer mortality in a retrospective cohort based on data from the 2015 health check-ups of residents in Quzhou City. After a mean follow-up of 5.31 years for 148,755 study participants, 10,345 deaths occurred, with an all-cause mortality density of 131.09/10,000 person-years, of which 2,845 were cancer deaths, with a cancer mortality density of 36.05/10,000 person-years. There was a "J" shaped dose-response relationship between fasting plasma glucose levels and all-cause and cancer mortality. Relative to normal fasting glucose (NFG), the risk of all-cause mortality (HRs and 95% CIs) in the impaired fasting glucose (IFG) and diabetes mellitus (DM) groups was 1.11 (1.06, 1.16) and 1.43 (1.35, 1.52), respectively, and the risk of cancer mortality in the DM group was 1.22 (1.09, 1.37). In this cohort study, we found that fasting plasma glucose levels were significantly associated with the risk of all-cause and cancer mortality.
尽管越来越多的研究表明空腹血糖水平与死亡率之间存在关联，但空腹血糖与全因和癌症死亡率之间的关系仍然不一致。在这项基于衢州市居民 2015 年健康检查数据的回顾性队列研究中，我们使用 Cox 回归和限制立方样条模型分析了空腹血浆葡萄糖水平与全因和癌症死亡率之间的关联和剂量-反应关系。在 148755 名研究参与者平均随访 5.31 年后，发生了 10345 例死亡，全因死亡率密度为 131.09/10000 人年，其中 2845 例死于癌症，癌症死亡率密度为 36.05/10000 人年。空腹血浆葡萄糖水平与全因和癌症死亡率之间存在“J”形剂量-反应关系。与正常空腹血糖（NFG）相比，空腹血糖受损（IFG）和糖尿病（DM）组的全因死亡率风险分别为 1.11（1.06，1.16）和 1.43（1.35，1.52），DM 组的癌症死亡率风险为 1.22（1.09，1.37）。在这项队列研究中，我们发现空腹血浆葡萄糖水平与全因和癌症死亡率的风险显著相关。
