通过血液学指标鉴别β地中海贫血特征与缺铁性贫血。
Differentiation of beta thalassemia trait from iron deficiency anemia by hematological indices.
作者信息
Jameel Tahir, Baig Mukhtiar, Ahmed Ijaz, Hussain Muhammad Barakat, Alkhamaly Motlag Bin Doghaim
机构信息
Prof. Tahir Jameel, FCPS. Professor of Clinical Hematology, Faculty of Medicine, Rabigh, King Abdul-Aziz University, Jeddah, Saudi Arabia.
Prof. Mukhtiar Baig, PhD. Professor of Clinical Biochemistry, Faculty of Medicine, Rabigh, King Abdul-Aziz University, Jeddah, Saudi Arabia.
出版信息
Pak J Med Sci. 2017 May-Jun;33(3):665-669. doi: 10.12669/pjms.333.12098.
OBJECTIVE
We aimed at finding out reliable parameter in the differentiation of iron deficiency anemia (IDA) and beta-thalassemia trait (β-TT) in the adult population subjected to Saudi Arabian Premarital Screening Program.
METHODS
A total of 620 adults (age range 21-36 years) reported during February 2012 to November 2012. Tests for serum iron and ferritin were carried out in individuals showing low hemoglobin (Hb). All the selected subjects' samples were subjected to blood morphology, comparison of MCV, RBC count. Red Cell Distribution Width (RDW) was noted from the Coulter Report whereas Red Cell Distribution Width Index (RDWI) value was calculated for all the samples.
RESULTS
A total of one hundred &thirty-five individuals with hypochromic microcytic anemia having normal hemoglobin F and hemoglobin A2 < 3.2% were inducted in the study. Ninety-three were diagnosed having IDA, whereas thirty-two were having βTT. Ten individuals revealed other causes of anemia. The RBC count was higher, and MCV was much lower in βTT as compared to IDA. Both groups were subjected to RDW and RDWI, however, RDWI which showed better sensitivity and specificity for βTT.
CONCLUSION
RDWI is a reliable and useful index for differentiation among IDA and βTT, as compared to RDW.
目的
我们旨在找出在接受沙特阿拉伯婚前筛查项目的成年人群中区分缺铁性贫血（IDA）和β地中海贫血特征（β-TT）的可靠参数。
方法
2012年2月至2012年11月期间共有620名成年人（年龄范围21 - 36岁）前来报告。对血红蛋白（Hb）低的个体进行血清铁和铁蛋白检测。所有选定受试者的样本均进行血液形态学检查、平均红细胞体积（MCV）比较、红细胞计数。红细胞分布宽度（RDW）从库尔特报告中获取，而所有样本均计算红细胞分布宽度指数（RDWI）值。
结果
共有135名血红蛋白F正常且血红蛋白A2 < 3.2%的低色素小细胞性贫血个体纳入研究。其中93人被诊断为IDA，32人患有β-TT。10人显示出其他贫血原因。与IDA相比，β-TT的红细胞计数更高，MCV更低。两组均进行了RDW和RDWI检测，然而，RDWI对β-TT显示出更好的敏感性和特异性。
结论
与RDW相比，RDWI是区分IDA和β-TT的可靠且有用的指标。
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