Yamamoto-Hanada Kiwako, Yang Limin, Ishitsuka Kazue, Ayabe Tadayuki, Mezawa Hidetoshi, Konishi Mizuho, Shoda Testsuo, Matsumoto Kenji, Saito Hirohisa, Ohya Yukihiro
Medical Support Center for the Japan Environment and Children's Study, National Center for Child Health and Development, Tokyo, Japan.
Division of Allergy, Department of Medical Subspecialties, National Center for Child Health and Development, 2-10-1, Okura, Setagayaku, Tokyo, 157-8535 Japan.
World Allergy Organ J. 2017 Aug 7;10(1):24. doi: 10.1186/s40413-017-0157-0. eCollection 2017.
The Japan Environment and Children's Study (JECS) is a nationwide, multicenter, prospective birth cohort investigation launched by the Ministry of Environment in Japan. The purpose of the JECS is to evaluate the influence of prenatal and postnatal exposures to environmental factors on the postnatal health of the children. In this study, we evaluated the allergic characteristics of parents within the JECS cohort.
This study covered a wide geographical area and encompassed 15 regional centers. We obtained information regarding doctor diagnosed allergic diseases by using maternal and/or paternal self-administered questionnaires during the first trimester of pregnancy. Blood samples were also obtained from mothers and/or fathers to detect serum IgE concentrations.
The prevalences of asthma, allergic rhinitis (hay fever), atopic dermatitis, and food allergy were 10.9, 36.0, 15.7 and 4.8%, respectively, among 99,013 mothers; these prevalences among 49,991 fathers were 10.8, 30.3, 11.2 and 3.3%, respectively. Any positive antigen-specific IgE sensitization was found in 73.9% of mothers. The most abundant antigen sensitization in mothers was to Japanese cedar (55.6%), followed by 1 (48%); only 1.0% of mothers were sensitized to egg white.
This is the first epidemiological report on allergic disorders and allergen sensitization of parents during pregnancy among the Japanese general population.
日本环境与儿童研究（JECS）是日本环境省发起的一项全国性、多中心前瞻性出生队列调查。JECS的目的是评估产前和产后暴露于环境因素对儿童出生后健康的影响。在本研究中，我们评估了JECS队列中父母的过敏特征。
本研究覆盖广泛地理区域，包括15个区域中心。我们通过在妊娠头三个月使用母亲和/或父亲的自填问卷获取有关医生诊断的过敏性疾病的信息。还从母亲和/或父亲采集血样以检测血清IgE浓度。
在99,013名母亲中，哮喘、过敏性鼻炎（花粉症）、特应性皮炎和食物过敏的患病率分别为10.9%、36.0%、15.7%和4.8%；在49,991名父亲中，这些患病率分别为10.8%、30.3%、11.2%和3.3%。73.9%的母亲存在任何阳性抗原特异性IgE致敏。母亲中最常见的抗原致敏是对日本雪松（55.6%），其次是1（48%）；只有1.0%的母亲对蛋清致敏。
这是关于日本普通人群中孕期父母过敏性疾病和过敏原致敏情况的首份流行病学报告。
