日本北海道孕妇血清桦树花粉IgE状态的相关因素：日本环境与儿童研究（JECS）

Factors correlating with serum birch pollen IgE status in pregnant women in Hokkaido, Japan: The Japan Environment and Children's Study (JECS).

作者信息

Saijo Yasuaki, Yoshioka Eiji, Sato Yukihiro, Miyamoto Toshinobu, Sengoku Kazuo, Ito Yoshiya, Itoh Sachiko, Miyashita Chihiro, Araki Atsuko, Kishi Reiko

机构信息

Department of Social Medicine, Asahikawa Medical University, Asahikawa, Japan.

Department of Obstetrics and Gynecology, Asahikawa Medical University, Asahikawa, Japan.

出版信息

World Allergy Organ J. 2020 Jul 3;13(6):100128. doi: 10.1016/j.waojou.2020.100128. eCollection 2020 Jun.

DOI:10.1016/j.waojou.2020.100128

PMID:32647557

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7338638/

Abstract

BACKGROUND

Birch pollen allergy affects pregnant women, and such allergy may affect the development of allergic diseases in their children. Using nationwide birth cohort data, this study aimed to investigate the prevalence of birch pollen IgE positivity and to identify correlating factors in pregnant women in Hokkaido, Japan, a high-latitude island.

METHODS

Participants included 6856 pregnant women. Participants responded to questionnaires regarding lifestyle factors and history of allergies. Data regarding parity, height, and pre-pregnancy weight were collected from medical records. Blood samples were obtained from participants during the first trimester of pregnancy, and serum allergen-specific IgE titers were determined.

RESULTS

The serum of 30.2% participants was positive for birch pollen IgE (≥0.35 UA/mL). Such positivity significantly correlated with a history of other allergic diseases, particularly food allergy and allergic rhinitis/hay fever. In multivariate logistic regression analysis, pre-pregnancy high body mass index (BMI ≥ 25) significantly correlated with birch pollen IgE positivity [odds ratio (OR), 1.24; 95% CI, 1.05-1.47; reference BMI, 18.5-24.9] and higher income (≥10 million yen per year; OR,0.55; 95% CI, 0.37-0.81; reference, household income < 2 million yen per year), and second quintile level physical activity (OR,0.75; 95% CI, 0.63-0.88; reference, the first quintile of physical activity) had significant protective effects.

CONCLUSIONS

Birch pollen IgE positivity in pregnant women was positively associated with food allergy, allergic rhinitis, pre-pregnant high BMI, and was negatively associated with light exercise and high household income in Hokkaido.

TRIAL REGISTRATION

UMIN000030786.

摘要

背景

桦树花粉过敏会影响孕妇，且这种过敏可能会影响其子女过敏性疾病的发展。本研究利用全国出生队列数据，旨在调查日本高纬度岛屿北海道孕妇中桦树花粉IgE阳性的患病率，并确定相关因素。

方法

参与者包括6856名孕妇。参与者回答了有关生活方式因素和过敏史的问卷。从医疗记录中收集有关产次、身高和孕前体重的数据。在妊娠早期从参与者身上采集血样，并测定血清过敏原特异性IgE滴度。

结果

30.2%参与者的血清桦树花粉IgE呈阳性（≥0.35 UA/mL）。这种阳性与其他过敏性疾病史显著相关，尤其是食物过敏和过敏性鼻炎/花粉热。在多因素logistic回归分析中，孕前高体重指数（BMI≥25）与桦树花粉IgE阳性显著相关[比值比（OR），1.24；95%置信区间（CI），1.05 - 1.47；参考BMI，18.5 - 24.9]，高收入（≥每年1000万日元；OR，0.55；95% CI，0.37 - 0.81；参考，家庭年收入<200万日元）以及第二五分位数水平的体力活动（OR，0.75；95% CI，0.63 - 0.88；参考，体力活动的第一五分位数）具有显著的保护作用。