Curso de Farmácia, Instituto de Ciências Biológicas, Universidade de Passo Fundo, Campus I, Km 292, BR 285, Bairro São José, Passo Fundo, RS, CEP 99052-900, Brazil.
Faculdade de Medicina, Universidade de Passo Fundo, Instituto de Patologia, Rua Teixeira Soares 885, 99010-081, Passo Fundo, RS, Brazil.
Environ Sci Pollut Res Int. 2017 Oct;24(28):22673-22678. doi: 10.1007/s11356-017-9887-3. Epub 2017 Aug 16.
Ozone helps decontamination environments due to its oxidative power, however present toxicity when it is in high concentrations, by long periods of exposition. This study aimed to assess the safety of ozone generator air purifier at concentrations of 0.05 ppm in rats exposed to 3 and 24 h/day for 14 and 28 days. No significant differences are observed between groups in clinical signs, feed and water intake, relative body weight gain and relative weight of organs, macroscopy and microscopy of lungs, and oxidative plasma assay. In this exposure regime, ozone does not cause genotoxicity and no significant changes in pulmonary histology indicative of toxicity. Ozone generated in low concentrations, even in exposure regimes above the recommended is safe, both acute and sub-acute exposition.
臭氧因其氧化能力有助于环境净化，但在高浓度、长时间暴露下具有毒性。本研究旨在评估臭氧发生器空气净化器在浓度为 0.05ppm 时对大鼠的安全性，大鼠每天暴露 3 小时和 24 小时，分别暴露 14 天和 28 天。在临床症状、饲料和水的摄入、相对体重增加和器官相对重量、肺的大体和显微镜检查以及血浆氧化测定方面，各组之间均未观察到显著差异。在这种暴露条件下，臭氧不会引起遗传毒性，也不会对肺组织学产生明显变化，表明没有毒性。在低浓度下产生的臭氧，即使在高于推荐的暴露条件下，无论是急性还是亚急性暴露，都是安全的。
