Roselli Carla, Desideri Donatella, Feduzi Laura, Ugolini Lucia, Meli Maria Assunta
Department of Biomolecular Sciences, Urbino University Carlo Bo, P.zza Rinascimento 6, I-61029 Urbino, Italy.
J Radiol Prot. 2017 Dec;37(4):907-917. doi: 10.1088/1361-6498/aa869b.
This study aims to investigate the bioaccessibility of Po in seafood and the impact of food preparation on this radionuclide. Polonium bioaccessibility is the fraction of Po mobilised from food matrices into digestive extractants when applying an in vitro digestion model. The degree of bioaccessibility of Po in food has important implications for estimating ingestion doses from this radionuclide. The simulation of gastrointestinal digestion was divided into three stages through the use of synthetic saliva, gastric and bile-pancreas solutions. Following pre-treatment with a saliva solution, raw and cooked seafood samples underwent one of the following treatments: (a) simulated gastric digestion only or (b) simulated complete gastrointestinal digestion (gastric digestion followed by bile-pancreas digestion). No significant difference (P > 0.05) in Po mobility was found between samples that underwent gastric digestion compared to those that only underwent gastro-intestinal digestion. However, a significant difference (P < 0.05) in Po bioaccessibility was found between raw and cooked seafood undergoing both gastric and gastro-intestinal digestion.
本研究旨在调查海产品中钋的生物可及性以及食品加工对这种放射性核素的影响。钋的生物可及性是指在应用体外消化模型时，从食物基质中转移到消化提取剂中的钋的比例。食物中钋的生物可及程度对于估算该放射性核素的摄入剂量具有重要意义。通过使用合成唾液、胃液和胆胰液，将胃肠道消化模拟分为三个阶段。在用唾液溶液进行预处理后，生的和熟的海产品样品接受以下处理之一：(a) 仅模拟胃消化或 (b) 模拟完整的胃肠道消化（胃消化后进行胆胰消化）。与仅进行胃肠道消化的样品相比，进行胃消化的样品在钋迁移率方面未发现显著差异（P > 0.05）。然而，在进行胃消化和胃肠道消化的生熟海产品之间，钋的生物可及性存在显著差异（P < 0.05）。
