a Department of Biomolecular Sciences , Urbino University "Carlo Bo" , Urbino , Italy.
J Toxicol Environ Health A. 2018;81(8):212-217. doi: 10.1080/15287394.2018.1436480. Epub 2018 Feb 13.
This study aimed to investigate the bioaccessibility of toxic elements, including aluminum (Al), arsenic (As), nickel (Ni), cadmium (Cd), and lead (Pb) in five commercial algae consumed by humans in Italy. The degree of bioaccessibility of these elements may have important implications for human health. Simulation of gastrointestinal tract (GIT) digestion was divided into three stages through use of synthetic saliva, gastric, and bile-pancreas solutions. After pre-treatment with a saliva solution, seaweed samples underwent one of the following treatments: (1) simulated gastric digestion only or (2) simulated complete GIT digestion (gastric digestion followed by bile-pancreas digestion). The bioaccessibility of these toxic elements ranged from approximately 5% to 73% and from 4% to 77% in gastric and GIT digestion, respectively. The bioaccessibility of Al and Pb is poor (5-15%), As and Ni were fairly (40-55%), while Cd displayed a high bioaccessibility. No significant differences in toxic elements mobility was found between samples that only underwent gastric digestion compared to those that underwent a complete GIT digestion.
本研究旨在调查人类在意大利食用的五种商业海藻中有毒元素（包括铝（Al）、砷（As）、镍（Ni）、镉（Cd）和铅（Pb））的生物可给性。这些元素的生物可给性程度可能对人类健康有重要影响。通过使用合成唾液、胃和胆汁-胰腺溶液，将胃肠道（GIT）消化模拟分为三个阶段。在唾液溶液预处理后，海藻样品进行以下处理之一：（1）仅模拟胃消化或（2）模拟完整 GIT 消化（胃消化后胆汁-胰腺消化）。这些有毒元素的生物可给性分别在胃和 GIT 消化中约为 5%至 73%和 4%至 77%。Al 和 Pb 的生物可给性较差（5-15%），As 和 Ni 的生物可给性中等（40-55%），而 Cd 则显示出较高的生物可给性。仅进行胃消化的样品与进行完整 GIT 消化的样品之间，有毒元素的移动性没有显著差异。
