Fog R, Regeur L
Rev Neurol (Paris). 1986;142(11):856-9.
In pharmacological treatment of Gilles de la Tourette's syndrome neuroleptic (antipsychotic) drugs have been the most effective. This has led to the hypothesis of a relative dopaminergic overactivity in the brain. Animal studies with neuroleptic drugs different in their affinity to different dopamine areas as well as studies with drugs different in their selectivity to different receptors have, however, not shown direct correlations to the clinical response in the treatment of hyperkinetic syndromes. There is a trend that drugs with high affinity to striatal D2-receptors might be the most potent. Other attempts to change brain dopamine in different ways using cholinergic, GABAergic, and peptidergic drugs have given rather poor clinical results. The apparent importance of brain dopamine in a whole range of neuropsychiatric diseases may be due to the central role of basal dopaminergic areas as a relay station for a lot of neuronal pathways.
在抽动秽语综合征的药物治疗中，抗精神病药物最为有效。这引发了大脑中多巴胺能相对活动过度的假说。然而，对不同多巴胺区域亲和力不同的抗精神病药物的动物研究，以及对不同受体选择性不同的药物的研究，均未显示出与多动综合征治疗临床反应的直接关联。有一种趋势是，对纹状体D2受体具有高亲和力的药物可能最为有效。使用胆碱能、GABA能和肽能药物以不同方式改变脑内多巴胺的其他尝试，临床效果相当不佳。脑内多巴胺在一系列神经精神疾病中明显的重要性，可能是由于基底多巴胺能区域作为许多神经通路的中继站所起的核心作用。
