Erdmann R
Abteilung Klinische Psychiatrie und Psychotherapie der Medizinischen Hochschule Hannover.
Fortschr Neurol Psychiatr. 1996 Sep;64(9):362-6. doi: 10.1055/s-2007-996579.
Nicotine has various effects in the CNS, especially in dopaminergic and cholinergic systems, relevant in pathophysiology of neuropsychiatric movement disorders. Nicotine acutely reduce the symptomatology in Parkinson's disease. In neuroleptic-induced Parkinsonism (NIP) acute nicotine application induces positive changes of symptomatology. Chronic application, however, leads to a greater likelihood of NIP. The results concerning tardive dyskinesia are not consistent, but nicotine tends to exercise a positive influence on basic mechanisms. In the Gilles-de-la-Tourette syndrome nicotine reduces the severity and frequency of the tics given in combination with haloperidol.
尼古丁在中枢神经系统有多种作用，尤其是在多巴胺能和胆碱能系统中，这与神经精神性运动障碍的病理生理学相关。尼古丁能急性减轻帕金森病的症状。在抗精神病药物所致帕金森综合征（NIP）中，急性应用尼古丁可使症状产生积极变化。然而，长期应用会增加患NIP的可能性。关于迟发性运动障碍的结果并不一致，但尼古丁倾向于对基本机制产生积极影响。在 Gilles - de - la - Tourette 综合征中，尼古丁与氟哌啶醇联合使用时可减轻抽搐的严重程度和频率。
