Dencker S J, Fasth B G
Acta Psychiatr Scand. 1986 Dec;74(6):569-75. doi: 10.1111/j.1600-0447.1986.tb06286.x.
Eighty out-patients with neurotic disorders were studied in an integrated treatment model combining psychotherapy and psychotropics in a "conjoint marital therapy" setting. The spouses, who seemed a healthy group, were used as reporters, as controls and as participants in the psychotherapy. The pharmacological trial was a double-blind, cross-over study, comparing bromazepam and thioridazine after a placebo period. Bromazepam was more effective in controlling different anxiety symptoms and demonstrated more potent activating properties than thioridazine. Hostility symptoms, however, responded better to thioridazine. These findings were confirmed by ratings performed by patients, spouses and the investigator. Differences in drug preference and drop-out rate showed the same tendency. Nine weeks' continuous treatment did not change the differences found in the cross-over study. No pharmacological rebound symptoms were observed after drug withdrawal. The personality of the spouses was related to the outcome in the patients. Moreover, there was an obvious positive interaction between the psychotherapy given and the drug treatment.
在“联合婚姻治疗”环境中，采用心理治疗与精神药物相结合的综合治疗模式，对80名神经症门诊患者进行了研究。配偶们看似是一个健康群体，被用作报告者、对照者以及心理治疗的参与者。药物试验是一项双盲交叉研究，在经过安慰剂期后，比较溴西泮和硫利达嗪。溴西泮在控制不同焦虑症状方面更有效，并且比硫利达嗪表现出更强的激活特性。然而，敌对症状对硫利达嗪的反应更好。这些发现得到了患者、配偶和研究者所做评分的证实。药物偏好和脱落率的差异显示出相同的趋势。为期9周的持续治疗并未改变交叉研究中发现的差异。停药后未观察到药物反跳症状迹象。配偶的个性与患者的治疗结果相关。此外，所给予的心理治疗和药物治疗之间存在明显的积极相互作用。
