Saario I
Ann Clin Res. 1976 Apr;8(2):117-23.
Twenty paid healthy students volunteered for a doubleblind cross-over trial on the effects of two weeks' treatment with placebo, thioridazine and bromazepam on psychomotor skills. The doses used were thioridazine 10 mg t.i.d. during the first week and 20 mg t.i.d. during the second week, or 6 mg of bromazepam t.i.d. during two weeks choice reaction test, two co-ordination tests, a divided attention test, flicker fusion, and proprioception tests were used. The psychomotor skills were measured in the afternoon of the 7th and 14th day of each treatment, 30, 90 and 150 minutes after the second daily administration of the drug in combination with either an alcoholic or a placebo drink. There were no significant differences between the test weeks. Thioridazine alone resembled placebo and had no major combined effect with alcohol. Bromazepam impaired reactive and co-ordinative skills and attention deteriorated. The combination of bromazepam and alcohol potentiated the deterious effects of the single agents, and this effect was most remarkable at 30 minutes. The subjects also gave exaggerated responses in the proprioceptive tests. No significant alterations were recorded in the flicker fusion frequency after any treatment.
20名有偿参与的健康学生自愿参加了一项双盲交叉试验，该试验旨在研究安慰剂、硫利达嗪和溴西泮为期两周的治疗对心理运动技能的影响。使用的剂量为：硫利达嗪在第一周每天三次，每次10毫克，第二周每天三次，每次20毫克；或溴西泮在两周内每天三次，每次6毫克。采用了选择反应测试、两项协调测试、一项注意力分散测试、闪烁融合测试和本体感觉测试。在每种治疗的第7天和第14天下午，在第二次每日给药药物后30、90和150分钟，同时给予酒精饮料或安慰剂饮料，测量心理运动技能。各测试周之间无显著差异。单独使用硫利达嗪的效果类似于安慰剂，与酒精无主要联合作用。溴西泮损害反应性和协调性技能，注意力下降。溴西泮和酒精的组合增强了单一药物的有害作用，这种作用在30分钟时最为显著。受试者在本体感觉测试中也给出了夸张的反应。任何治疗后闪烁融合频率均未记录到显著变化。
