Romero-Sánchez Consuelo, Malagón Clara, Vargas Camilo, Fernanda Torres María, Moreno Lorena Chila, Rodríguez Constanza, Castillo Diana Marcela, De Avila Juliette, Mosquera Ángela Catalina, Lafaurie Gloria Inés
Associate professor, in the Unit of Oral Basic Investigation, School of Dentistry, at the Universidad El Bosque, in Bogotá, Bacteriologist, Department of Rheumatology and Immunology, Hospital Militar Central, in Bogotá, Colombia;, Email:
Assistant professor, Staff pediatrician, Department of Pediatrics, School of Medicine, at the Universidad El Bosque, in Bogotá, Colombia.
J Dent Child (Chic). 2017 May 15;84(2):72-79.
The purpose of this study was to evaluate the periodontal status and the presence and concentration of Porphyromonas gingivalis (P. gingivalis) and immunoglobulin G (IgG) subclass against P. gingivalis in juvenile idiopathic arthritis (JIA) and its association with rheumatic clinical activity parameters.
Rheumatologic conditions and periodontal status were clinically assessed in 51 patients with JIA. P. gingivalis, IgG1 and IgG2, high-sensitivity C-reactive protein, erythrocyte sedimentation rate, rheumatoid factor (RF), anti-citrullinated protein antibodies (ACPAs), and human leukocyte antigen B27 were also evaluated.
Periodontitis was observed in 21.5 percent of the patients, 23.5 percent of whom were positive for P. gingivalis, which was associated with enthesitis-related arthritis (P<0.035). IgG1 against P gingivalis was associated with RF autoantibodies (P=0.05), and all patients positive for ACPAs had higher anti-P gingivalis IgG1 levels. A significant correlation was found between the presence of limited joint mobility and the plaque index in polyarticular JIA (r=0.55, P=0.028).
An association between IgG and rheumatic disease activity markers in JIA was evident. It is important to investigate the familiar periodontal status and clinical course in JIA, especially in enthesitis-related arthritis.
本研究旨在评估青少年特发性关节炎（JIA）患者的牙周状况、牙龈卟啉单胞菌（P. gingivalis）的存在及浓度、抗牙龈卟啉单胞菌免疫球蛋白G（IgG）亚类，并探讨其与风湿临床活动参数的关联。
对51例JIA患者进行了风湿病病情及牙周状况的临床评估。同时还评估了牙龈卟啉单胞菌、IgG1和IgG2、高敏C反应蛋白、红细胞沉降率、类风湿因子（RF）、抗瓜氨酸化蛋白抗体（ACPAs）以及人类白细胞抗原B27。
21.5%的患者观察到牙周炎，其中23.5%的患者牙龈卟啉单胞菌呈阳性，这与附着点炎相关关节炎有关（P<0.035）。抗牙龈卟啉单胞菌IgG1与RF自身抗体有关（P=0.05），所有ACPAs阳性患者的抗牙龈卟啉单胞菌IgG1水平更高。在多关节型JIA中，关节活动受限的存在与菌斑指数之间存在显著相关性（r=0.55，P=0.028）。
JIA中IgG与风湿疾病活动标志物之间的关联明显。对JIA患者，尤其是附着点炎相关关节炎患者，调查其家族牙周状况和临床病程很重要。
