Zekre Franck, Cimaz Rolando, Paul Mireille, Giani Teresa, Waeckel Louis, Berger Anne-Emmanuelle, Stephan Jean-Louis, Normand Myriam, Paul Stéphane, Marotte Hubert
LBTO Team, INSERM, 1059, SAINBIOSE (SAnté INgéniérie BIOlogie St-Etienne), Université Jean Monnet, 42055 Saint-Etienne, France.
CIRI (Centre International de Recherche en Infectiologie), Équipe GIMAP (Team 15), INSERM U1111, CNRS, ENS, UCBL1, Université Jean Monnet, Université de Lyon, 42055 Saint-Etienne, France.
Biomedicines. 2022 Oct 18;10(10):2613. doi: 10.3390/biomedicines10102613.
(1) Background: The link between periodontal disease and rheumatoid arthritis (RA) is now widely reported. Several studies suggest the role of () in the pathophysiology of RA and some observations highlight the improvement of the disease activity induced by therapies against . We have very little data on the prevalence of carriage in patients with juvenile idiopathic arthritis (JIA) and its possible involvement in the pathophysiology of inflammatory joint diseases in children. (2) Methods: The specific IgG responses against and () were determined in a cohort of 101 patients with JIA and 19 patients with other autoimmune diseases (inflammatory bowel disease and type 1 diabetes). (3) Results: Specific anti- and anti- IgG titers were higher in JIA group than in control groups. These differences were mainly observed in the oligoarthritis group. The same pattern was observed in enthesitis-related arthritis (ERA). (4) Conclusions: Children with oligoarticular and ERA subsets had higher IgG titers to and . These results suggest involvement of an oral dysbiosis in the occurrence of JIA in these subgroups.
(1) 背景：牙周病与类风湿关节炎（RA）之间的联系如今已被广泛报道。多项研究提示（某因素）在RA病理生理学中的作用，一些观察结果突出了针对（某因素）的治疗所诱导的疾病活动改善情况。我们关于青少年特发性关节炎（JIA）患者中（某菌）携带率及其可能参与儿童炎性关节疾病病理生理学的数据非常少。(2) 方法：在一组101例JIA患者和19例其他自身免疫性疾病（炎性肠病和1型糖尿病）患者中测定针对（某菌）和（另一因素）的特异性IgG反应。(3) 结果：JIA组中特异性抗（某菌）和抗（另一因素）IgG滴度高于对照组。这些差异主要在少关节炎组中观察到。在附着点炎相关关节炎（ERA）中也观察到相同模式。(4) 结论：少关节型和ERA亚型的儿童对（某菌）和（另一因素）的IgG滴度较高。这些结果提示口腔生态失调参与了这些亚组JIA的发生。
