海洋花青素，一种来自链霉菌属进化枝MAR4的海洋细菌产生的具有细胞毒性的溴代吩嗪酮杂萜类化合物。
Marinocyanins, cytotoxic bromo-phenazinone meroterpenoids from a marine bacterium from the streptomycete clade MAR4.
作者信息
Asolkar Ratnakar N, Singh Ahilya, Jensen Paul R, Aalbersberg William, Carté Brad K, Feussner Klaus-D, Subramani Ramesh, DiPasquale Antonio, Rheingold Arnold L, Fenical William
机构信息
Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California, San Diego, La Jolla, CA, 92093-0204, USA.
Institute of Applied Sciences, Faculty of Science, Technology and Environment, The University of the South Pacific, Laucala Campus, Private Mail Bag, Suva, Fiji.
出版信息
Tetrahedron. 2017 Apr 20;73(16):2234-2241. doi: 10.1016/j.tet.2017.03.003. Epub 2017 Mar 6.
Six cytotoxic and antimicrobial metabolites of a new bromo-phenazinone class, the marinocyanins A-F (-), were isolated together with the known bacterial metabolites 2-bromo-1-hydroxyphenazine (), lavanducyanin ( WS-9659A) and its chlorinated analog WS-9659B (). These metabolites were purified by bioassay-guided fractionation of the extracts of our MAR4 marine actinomycete strains CNS-284 and CNY-960. The structures of the new compounds were determined by detailed spectroscopic methods and marinocyanin A () was confirmed by crystallographic methods. The marinocyanins represent the first bromo-phenazinones with an -isoprenoid substituent in the skeleton. Marinocyanins A-F show strong to weak cytotoxicity against HCT-116 human colon carcinoma and possess modest antimicrobial activities against and amphotericin-resistant .
从我们的MAR4海洋放线菌菌株CNS - 284和CNY - 960的提取物中，通过生物测定导向分级分离法，分离出了一类新的溴代吩嗪酮类的六种细胞毒性和抗菌代谢产物，即海蓝菌素A - F（-），同时还分离出了已知的细菌代谢产物2 - 溴 - 1 - 羟基吩嗪（）、薰衣草花青素（WS - 9659A）及其氯化类似物WS - 9659B（）。通过详细的光谱方法确定了新化合物的结构，海蓝菌素A（）通过晶体学方法得到证实。海蓝菌素是骨架中带有异戊二烯取代基的首批溴代吩嗪酮。海蓝菌素A - F对HCT - 116人结肠癌显示出强至弱的细胞毒性，并且对和两性霉素耐药的具有适度的抗菌活性。
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