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链霉菌属CNQ-509的全基因组序列,多聚萜类化合物的高产生产者

Complete genome sequence of Streptomyces sp. CNQ-509, a prolific producer of meroterpenoid chemistry.

作者信息

Rückert Christian, Leipoldt Franziska, Zeyhle Philipp, Fenical William, Jensen Paul R, Kalinowski Jörn, Heide Lutz, Kaysser Leonard

机构信息

Technology Platform Genomics, Center for Biotechnology, Bielefeld University, Bielefeld, Germany.

Pharmaceutical Institute, Tübingen University, Tübingen, Germany; German Centre for Infection Research (DZIF), Partner Site Tübingen, Germany.

出版信息

J Biotechnol. 2015 Dec 20;216:140-1. doi: 10.1016/j.jbiotec.2015.08.009. Epub 2015 Aug 28.

Abstract

Streptomyces sp. CNQ-509 is a marine actinomycete belonging to the MAR4 streptomycete lineage. MAR4 strains have been linked to the production of diverse and otherwise rare meroterpenoid compounds. The genome sequence of Streptomyces sp. CNQ-509 was found to contain 29 putative gene clusters for the biosynthesis of secondary metabolites, some of them potentially involved in the formation of meroterpenoid molecules.

摘要

链霉菌属CNQ-509是一种属于MAR4链霉菌谱系的海洋放线菌。MAR4菌株与多种不同寻常的罕见杂萜类化合物的产生有关。链霉菌属CNQ-509的基因组序列被发现包含29个假定的次生代谢物生物合成基因簇,其中一些可能参与杂萜类分子的形成。

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