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提取物通过激活水通道蛋白-5调节唾液分泌，并预防糖尿病引起的口干症。

extract regulates salivary secretion through the activation of aquaporin-5 and prevents diabetes-induced xerostomia.

作者信息

Bhattarai Kashi Raj, Lee Sang-Won, Kim Seung Hyun, Kim Hyung-Ryong, Chae Han-Jung

机构信息

Department of Pharmacology and Institute of New Drug Development, School of Medicine, Chonbuk National University, Jeonju.

Department of Herb Crop Resources, National Institute of Horticultural and Herbal Science, Rural Development Administration, Eumseong-gun.

出版信息

J Exp Pharmacol. 2017 Jul 31;9:81-91. doi: 10.2147/JEP.S141807. eCollection 2017.

DOI:10.2147/JEP.S141807
PMID:28814903
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5546769/
Abstract

The aim of this study was to investigate the effects of (IXD) extract to improve the salivation rate in dry mouth induced by diabetes. Both control and diabetic rats were treated with a sublingual spray of either water or IXD extract to determine the effects of IXD on salivation. During the study, we observed that IXD extract treatment increased the salivary flow rate in diabetic rats. The expression of α-amylase was increased significantly in both saliva and glandular tissue lysates of IXD-treated diabetic rats. Aquaporin-5 protein expression was abnormally low in the salivary glands of diabetic rats, which increased hyposalivation and led to salivary dysfunction. However, a single oral spray of IXD extract drastically increased the expression of aquaporin-5 in salivary gland acinar and ductal cells in diabetic rats. Moreover, IXD extract induced expression of Na/H exchangers in the salivary gland, which suggests that Na/H exchangers modulate salivary secretions and aid in the fluid-secretion mechanism. Furthermore, transient treatment with IXD extract increased the intracellular calcium in human salivary gland cells. Taken together, these results suggest the potential value of an IXD extract for the treatment of diabetes-induced hyposalivation and xerostomia.

摘要

本研究的目的是探讨（IXD）提取物对改善糖尿病所致口干症唾液分泌率的影响。对对照组和糖尿病大鼠进行舌下喷注水或IXD提取物，以确定IXD对唾液分泌的影响。在研究过程中，我们观察到IXD提取物治疗可提高糖尿病大鼠的唾液流速。在接受IXD治疗的糖尿病大鼠的唾液和腺组织裂解物中，α-淀粉酶的表达均显著增加。水通道蛋白-5在糖尿病大鼠唾液腺中的蛋白表达异常低，这增加了唾液分泌减少并导致唾液功能障碍。然而，单次口服IXD提取物可显著增加糖尿病大鼠唾液腺腺泡和导管细胞中水通道蛋白-5的表达。此外，IXD提取物诱导唾液腺中钠/氢交换体的表达，这表明钠/氢交换体调节唾液分泌并有助于液体分泌机制。此外，用IXD提取物进行短暂治疗可增加人唾液腺细胞内的钙含量。综上所述，这些结果表明IXD提取物在治疗糖尿病引起的唾液分泌减少和口干症方面具有潜在价值。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f220/5546769/fc9b3f2876b5/jep-9-081Fig8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f220/5546769/6374f5e342fb/jep-9-081Fig1.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f220/5546769/fc9b3f2876b5/jep-9-081Fig8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f220/5546769/6374f5e342fb/jep-9-081Fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f220/5546769/b2dc9dcb76d9/jep-9-081Fig2.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f220/5546769/fc9b3f2876b5/jep-9-081Fig8.jpg

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