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维护反科学的线性无阈值谬论:权威、不可知论、透明度与医疗标准

Preserving the Anti-Scientific Linear No-Threshold Myth: Authority, Agnosticism, Transparency, and the Standard of Care.

作者信息

Sacks Bill, Siegel Jeffry A

机构信息

PostFDA's Center for Devices and Radiological Health, Green Valley, AZ, USA.

Nuclear Physics Enterprises, Marlton, NJ, USA.

出版信息

Dose Response. 2017 Jul 14;15(3):1559325817717839. doi: 10.1177/1559325817717839. eCollection 2017 Jul-Sep.

DOI:10.1177/1559325817717839
PMID:28814947
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5548321/
Abstract

The linear no-threshold (LNT) assumption is over 70 years old and holds that all ionizing radiation exposure leaves cumulative effects, all of which are harmful regardless of how low the dose or dose rate is. The claimed harm centers on the risk of future radiogenic cancer. This has been shown countless times to be fallacious, and hundreds of scientific studies-both experimental and observational/epidemiological-demonstrate that at low enough doses and dose rates, ionizing radiation stimulates an evolved adaptive response and therefore is beneficial to health, rather than raising the risk of cancer. Yet the myth of uncorrected lifetime cumulative risk still pervades the field of radiation science and underlies the policies of virtually all regulatory agencies around the world. This article explores some of the motivations behind, and methods used to assure, the extreme durability of the LNT myth in the face of the preponderance of contrary evidence and the manifest harms of radiophobia. These include subservience to the voice of authority, tactics such as claiming agnosticism on behalf of the entire field, transparent references to contrary evidence while dismissing the findings without refutation, and seeking shelter behind the legally protective medical standard of care.

摘要

线性无阈(LNT)假设有70多年的历史了,它认为所有电离辐射暴露都会产生累积效应,无论剂量或剂量率有多低,所有这些效应都是有害的。所谓的危害集中在未来辐射诱发癌症的风险上。这已被无数次证明是错误的,数百项科学研究——包括实验性研究和观察性/流行病学研究——表明,在足够低的剂量和剂量率下,电离辐射会激发一种进化而来的适应性反应,因此对健康有益,而不是增加患癌风险。然而,未经修正的终身累积风险的神话仍然在辐射科学领域盛行,并且几乎是世界上所有监管机构政策的基础。本文探讨了在面对大量相反证据和辐射恐惧症明显危害的情况下,LNT神话极端持久的一些背后动机和用以确保其存在的方法。这些包括屈从于权威的声音、诸如代表整个领域宣称不可知论的策略、在驳回研究结果而不反驳的同时透明地提及相反证据,以及寻求法律保护性医疗护理标准的庇护。

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本文引用的文献

1
Advocating for use of the ALARA principle in the context of medical imaging fails to recognize that the risk is hypothetical and so serves to reinforce patients' fears of radiation.在医学成像领域倡导使用“尽可能合理达到低水平”(ALARA)原则,却未能认识到这种风险是假设性的,因此反而加剧了患者对辐射的恐惧。
Med Phys. 2017 Jan;44(1):3-6. doi: 10.1002/mp.12012. Epub 2017 Jan 3.
2
The Controversial Linear No-Threshold Model.有争议的线性无阈模型。
J Nucl Med. 2017 Jan;58(1):7-8. doi: 10.2967/jnumed.116.182667. Epub 2016 Oct 6.
3
Letting go of what we believe about radiation and the risk of cancer in children.放下我们对辐射以及儿童患癌风险的固有认知。
Pediatr Radiol. 2017 Jan;47(1):113-115. doi: 10.1007/s00247-016-3697-5. Epub 2016 Oct 14.
4
Subjecting Radiologic Imaging to the Linear No-Threshold Hypothesis: A Non Sequitur of Non-Trivial Proportion.将放射影像学置于线性无阈假说之下:一个具有相当比例的不合逻辑的推理。
J Nucl Med. 2017 Jan;58(1):1-6. doi: 10.2967/jnumed.116.180182. Epub 2016 Aug 4.
5
Epidemiology Without Biology: False Paradigms, Unfounded Assumptions, and Specious Statistics in Radiation Science (with Commentaries by Inge Schmitz-Feuerhake and Christopher Busby and a Reply by the Authors).没有生物学的流行病学:辐射科学中的错误范式、无端假设和似是而非的统计数据(英格·施密茨 - 费尔哈克和克里斯托弗·巴斯比的评论及作者的回应)
Biol Theory. 2016;11:69-101. doi: 10.1007/s13752-016-0244-4. Epub 2016 Jun 17.
6
Risk of cancer from occupational exposure to ionising radiation: retrospective cohort study of workers in France, the United Kingdom, and the United States (INWORKS).职业性接触电离辐射导致癌症的风险:法国、英国和美国工人的回顾性队列研究(INWORKS)
BMJ. 2015 Oct 20;351:h5359. doi: 10.1136/bmj.h5359.
7
Ionising radiation in the workplace.工作场所中的电离辐射。
BMJ. 2015 Oct 20;351:h5405. doi: 10.1136/bmj.h5405.
8
Ionising radiation and risk of death from leukaemia and lymphoma in radiation-monitored workers (INWORKS): an international cohort study.辐射监测工作人员的电离辐射与白血病和淋巴瘤死亡风险(INWORKS):一项国际队列研究
Lancet Haematol. 2015 Jul;2(7):e276-81. doi: 10.1016/S2352-3026(15)00094-0.
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On the origins of the linear no-threshold (LNT) dogma by means of untruths, artful dodges and blind faith.线性无阈值(LNT)教条的起源是通过谎言、巧妙回避和盲目信仰。
Environ Res. 2015 Oct;142:432-42. doi: 10.1016/j.envres.2015.07.011. Epub 2015 Aug 4.
10
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