Cozanitis D A, Pouttu J, Rosenberg P H
Anaesthesia. 1987 Feb;42(2):192-4. doi: 10.1111/j.1365-2044.1987.tb02998.x.
One hundred and twenty patients undergoing anaesthesia for elective surgery received either pancuronium or vecuronium for muscle relaxation. Within each of these two groups, half were given glycopyrronium and the remainder an inert placebo. The incidence of bradycardia or bradydysrhythmias was higher in the group having vecuronium compared with those given pancuronium. Glycopyrronium afforded protection against undesirable vagal activity.
120例接受择期手术麻醉的患者接受泮库溴铵或维库溴铵以实现肌肉松弛。在这两组患者中，每组有一半接受格隆溴铵，其余接受惰性安慰剂。与接受泮库溴铵的患者相比，接受维库溴铵的患者心动过缓或缓慢性心律失常的发生率更高。格隆溴铵可预防不良的迷走神经活动。
