Zhang Xinyuan, Zhao Lin, Hambly Brett, Bao Shisan, Wang Kaiyue
Beijing Institute of Ophthalmology, Beijing Tongren Eye Center, Tongren Hospital, Beijing Ophthalmology & Visual Sciences Key Lab, Capital Medical University, Beijing, 100730 People's Republic of China.
Charles Perkins Centre, The University of Sydney, Level 4 West, D17, Camperdown, NSW 2006 Australia.
Cell Biosci. 2017 Aug 15;7:42. doi: 10.1186/s13578-017-0167-1. eCollection 2017.
In recent years, considerable progress has been made in the molecular mechanisms of epigenetics in disease development and progression, the reversible characteristics of epigenetic modification provide new insights for the treatment of such diseases. The pathogenesis of diabetic retinopathy (DR) has not yet been fully understood, treatment of refractory and recurrent diabetic macular edema remains a big change in clinical practice. This review emphasizes that reversibility of epigenetic modification could provide a new strategy for the prevention and treatment of diseases.
近年来，表观遗传学在疾病发生发展中的分子机制取得了显著进展，表观遗传修饰的可逆特性为这类疾病的治疗提供了新的思路。糖尿病视网膜病变（DR）的发病机制尚未完全明确，难治性和复发性糖尿病黄斑水肿的治疗仍是临床实践中的一大挑战。本综述强调表观遗传修饰的可逆性可为疾病的防治提供新策略。
