Department of Ophthalmology, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, China.
Shanghai Key Laboratory of Orbital Diseases and Ocular Oncology, Shanghai 200011, China.
Int J Mol Sci. 2022 Jun 23;23(13):7005. doi: 10.3390/ijms23137005.
Diabetic retinopathy is the major blinding disease among working-age populations, which is becoming more significant due to the growth of diabetes. The metabolic-induced oxidative and inflammatory stress leads to the insult of neovascular unit, resulting in the core pathophysiology of diabetic retinopathy. Existing therapies focus on the inflammation, oxidation, and angiogenesis phenomena of diabetic retinopathy, without effect to radically cure the disease. This review also summarizes novel therapeutic attempts for diabetic retinopathy along with their advantages and disadvantages, mainly focusing on those using cellular and genetic techniques to achieve remission on a fundamental level of disease.
糖尿病性视网膜病变是工作年龄段人群中主要的致盲性疾病，由于糖尿病的增长，这一问题变得更加严重。代谢引起的氧化和炎症应激导致新生血管单元受到损伤，导致糖尿病性视网膜病变的核心病理生理学。现有的治疗方法主要集中在糖尿病性视网膜病变的炎症、氧化和血管生成现象上，而没有从根本上治愈疾病的效果。本综述还总结了糖尿病性视网膜病变的新的治疗尝试及其优缺点，主要集中在使用细胞和基因技术从疾病的根本水平实现缓解的那些尝试上。
