Li Xiaohua, Ma Binyun, Zhang Wenfang, Song Zongming, Zhang Xiaodan, Liao Mengyu, Li Xue, Zhao Xueru, Du Mei, Yu Jinguo, He Shikun, Yan Hua
Henan Provincial People's Hospital, Henan Eye Hospital, Henan Eye Institute, Henan Key Laboratory of Ophthalmology and Visual Science, People's Hospital of Zhengzhou University, People's Hospital of Henan University, Zhengzhou, Henan 450003, China.
Department of Medicine/Hematology, Keck School of Medicine of the University of Southern California, Los Angeles, CA 90033, USA.
Genes Dis. 2022 May 26;10(2):505-520. doi: 10.1016/j.gendis.2022.05.008. eCollection 2023 Mar.
There are many complex eye diseases which are the leading causes of blindness, however, the pathogenesis of the complex eye diseases is not fully understood, especially the underlying molecular mechanisms of N6-methyladenosine (m6A) RNA methylation in the eye diseases have not been extensive clarified. Our review summarizes the latest advances in the studies of m6A modification in the pathogenesis of the complex eye diseases, including cornea disease, cataract, diabetic retinopathy, age-related macular degeneration, proliferative vitreoretinopathy, Graves' disease, uveal melanoma, retinoblastoma, and traumatic optic neuropathy. We further discuss the possibility of developing m6A modification signatures as biomarkers for the diagnosis of the eye diseases, as well as potential therapeutic approaches.
有许多复杂的眼部疾病是导致失明的主要原因，然而，这些复杂眼部疾病的发病机制尚未完全明确，尤其是眼部疾病中N6-甲基腺苷（m6A）RNA甲基化的潜在分子机制尚未得到广泛阐明。我们的综述总结了m6A修饰在复杂眼部疾病发病机制研究中的最新进展，包括角膜疾病、白内障、糖尿病视网膜病变、年龄相关性黄斑变性、增殖性玻璃体视网膜病变、格雷夫斯病、葡萄膜黑色素瘤、视网膜母细胞瘤和外伤性视神经病变。我们进一步讨论了开发m6A修饰特征作为眼部疾病诊断生物标志物的可能性，以及潜在的治疗方法。
