Kosior-Jarecka Ewa, Wróbel-Dudzińska Dominika, Łukasik Urszula, Żarnowski Tomasz
Department of Diagnostics and Microsurgery of Glaucoma, Medical University of Lublin, Lublin, Poland.
J Ophthalmol. 2017;2017:1480746. doi: 10.1155/2017/1480746. Epub 2017 Jul 26.
The aim of this study was to assess general and ocular profiles of patients with single-localisation changes in visual field.
The study group consisted of 215 Caucasian patients with normal-tension glaucoma with scotoma on single localisation or with preperimetric glaucoma. During regular follow-up visits, ophthalmic examination was carried out and medical history was recorded. The results of the visual field were allocated as paracentral scotomas, arcuate scotomas, peripheral defects, or hemispheric defects. Statistical analysis was conducted with Statistica 12, and < 0.05 was considered statistically significant.
Risk factors such as notch, disc hemorrhage, general hypertension, migraine, and diabetes were strongly associated with specific visual field defects. Paracentral defect was significantly more frequent for women ( = 0.05) and patients with disc hemorrhage ( < 0.001). Arcuate scotoma occurred frequently in patients without disc hemorrhage ( = 0.046) or migraines ( = 0.048) but was observed in coexistence with general hypertension ( < 0.001). The hemispheric defect corresponded with notch ( = 0.0036) and migraine ( = 0.081). Initial IOP was highest in patients with arcuate scotoma and lowest in patients with preperimetric glaucoma ( = 0.0120).
The specific morphology of scotoma in patients with normal-tension glaucoma is connected with definite general and ocular risk factors.
本研究旨在评估视野单部位改变患者的全身及眼部情况。
研究组由215例白种人患者组成，这些患者患有眼压正常性青光眼且存在单部位暗点或视野检查前青光眼。在定期随访期间，进行眼科检查并记录病史。视野检查结果分为旁中心暗点、弓形暗点、周边缺损或半球形缺损。使用Statistica 12进行统计分析，P<0.05被认为具有统计学意义。
诸如切迹、视盘出血、全身性高血压、偏头痛和糖尿病等危险因素与特定的视野缺损密切相关。旁中心缺损在女性患者（P = 0.05）和视盘出血患者中（P<0.001）明显更为常见。弓形暗点在无视盘出血（P = 0.046）或偏头痛（P = 0.048）的患者中频繁出现，但在合并全身性高血压的患者中也有观察到（P<0.001）。半球形缺损与切迹（P = 0.0036）和偏头痛（P = 0.081）相关。初始眼压在弓形暗点患者中最高，在视野检查前青光眼患者中最低（P = 0.0120）。
眼压正常性青光眼患者暗点的特定形态与明确的全身及眼部危险因素相关。
