Baillet F, Sabatini de la Foata J C, Maylin C, Froissart D, Martin M, Pierquin B
Rev Stomatol Chir Maxillofac. 1979;80(3):112-6.
The authors studied the factors which favour necrosis after curietherapy, in a series of 82 patients with epithelioma of the oral cavity and a previous series of 280 cases. The principal factor is the size of the tumor. The other factors (macroscopic appearance, dose, quantity of radioactive material, degree of inhomogeneity, distance between the lines, association with external irradiation), are or only moderate importance, as shown by the variations observed, though they are difficult to evaluate in an exact manner, partly for methodological reasons. The frequency of necrosis of bone tissue is directly relaxed to the number of radioactive lines in contact with the maxilla. Alcohol and tabacco abuse have a definite influence but this cannot be calculated. In conclusion, therefore, it would appear possible to reduce the frequency of necrotic lesions by reducing the tumoral size by curietherapy, by applying no more than 2 lines in contact with the mandible for bony necrotic lesions, and by stopping the abuse of alcohol and tobacco.
作者在82例口腔上皮瘤患者及之前的280例病例中，研究了有利于镭疗法后坏死的因素。主要因素是肿瘤大小。其他因素（宏观外观、剂量、放射性物质数量、不均匀程度、线间距离、与外照射联合使用）虽难以精确评估，部分是由于方法学原因，但从观察到的变化来看，其重要性一般或仅为中等。骨组织坏死的频率与接触上颌骨的放射性线数量直接相关。酗酒和吸烟有一定影响，但无法计算。因此，综上所述，似乎可以通过镭疗法减小肿瘤大小、对于骨坏死病变在下颌骨仅应用不超过2条接触线以及戒除酗酒和吸烟来降低坏死性病变的频率。
