了解长链非编码RNA在神经系统发育中的作用。
Understanding the Role of lncRNAs in Nervous System Development.
作者信息
Clark Brian S, Blackshaw Seth
机构信息
Johns Hopkins University School of Medicine, Baltimore, MD, USA.
出版信息
Adv Exp Med Biol. 2017;1008:253-282. doi: 10.1007/978-981-10-5203-3_9.
Abstract
The diversity of lncRNAs has expanded within mammals in tandem with the evolution of increased brain complexity, suggesting that lncRNAs play an integral role in this process. In this chapter, we will highlight the identification and characterization of lncRNAs in nervous system development. We discuss the potential role of lncRNAs in nervous system and brain evolution, along with efforts to create comprehensive catalogues that analyze spatial and temporal changes in lncRNA expression during nervous system development. Additionally, we focus on recent endeavors that attempt to assign function to lncRNAs during nervous system development. We highlight discrepancies that have been observed between in vitro and in vivo studies of lncRNA function and the challenges facing researchers in conducting mechanistic analyses of lncRNAs in the developing nervous system. Altogether, this chapter highlights the emerging role of lncRNAs in the developing brain and sheds light on novel, RNA-mediated mechanisms by which nervous system development is controlled.
摘要
随着哺乳动物大脑复杂性的增加，lncRNA的多样性也随之扩展，这表明lncRNA在这一过程中发挥着不可或缺的作用。在本章中，我们将重点介绍lncRNA在神经系统发育中的鉴定和特征。我们讨论了lncRNA在神经系统和大脑进化中的潜在作用，以及为创建综合目录所做的努力，这些目录用于分析神经系统发育过程中lncRNA表达的时空变化。此外，我们关注最近在尝试确定lncRNA在神经系统发育过程中的功能方面所做的努力。我们强调了在lncRNA功能的体外和体内研究中观察到的差异，以及研究人员在对发育中的神经系统中的lncRNA进行机制分析时所面临的挑战。总之，本章突出了lncRNA在发育中的大脑中的新兴作用，并揭示了控制神经系统发育的新的RNA介导机制。
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