筒箭毒碱和泮库溴铵抑制小鼠半膈肌标本中乙酰胆碱的诱发性释放。
Tubocurarine and pancuronium inhibit evoked release of acetylcholine from the mouse hemidiaphragm preparation.
作者信息
Vizi E S, Somogyi G T, Nagashima H, Duncalf D, Chaudhry I A, Kobayashi O, Goldiner P L, Foldes F F
出版信息
Br J Anaesth. 1987 Feb;59(2):226-31. doi: 10.1093/bja/59.2.226.
PMID:2881567
Abstract
Using a sensitive radioactive method that measures selectively the evoked release of acetylcholine, it was demonstrated that, when stimulating at 50 Hz, tubocurarine or pancuronium 2 X 10(-5) mol litre-1 or hexamethonium 10(-3) mol litre-1 significantly decreased the evoked release of acetylcholine in the mouse in vitro phrenic nerve-hemidiaphragm preparation.
摘要
采用一种能选择性测量乙酰胆碱诱发释放的灵敏放射性方法，结果表明，在体外小鼠膈神经 - 半膈肌标本中，当以50Hz频率刺激时，2×10⁻⁵mol/L的筒箭毒碱或泮库溴铵或10⁻³mol/L的六甲铵可显著降低乙酰胆碱的诱发释放。
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